Opening new paths for biological applications of ion mobility - mass spectrometry using Structures for Lossless Ion Manipulations.
Trends Analyt Chem
; 116: 300-307, 2019 Jul.
Article
in En
| MEDLINE
| ID: mdl-32831434
ABSTRACT
Ion mobility separations coupled to mass spectrometry (IM-MS) have received much attention for their ability to provide complementary structural information to solution-phase-based separations, as well as to aid in the identification of unknown compounds. While IM-MS is an increasingly powerful analytical technique, significant bottlenecks related to the resolution of measurements have kept it from becoming broadly applied for biological analyses. Presently, IM-MS-based measurements also remain limited in terms of their sensitivity as compared to state of the art MS-based approaches alone. Structures for Lossless Ion Manipulations (SLIM)-based IM separations provide a basis for overcoming these bottlenecks, addressing issues associated with resolution and sensitivity in the omics, and potentially opening the door to much broader application.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Trends Analyt Chem
Year:
2019
Type:
Article
Affiliation country:
United States