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The BCL-2 selective inhibitor ABT-199 sensitizes soft tissue sarcomas to proteasome inhibition by a concerted mechanism requiring BAX and NOXA.
Muenchow, Alina; Weller, Sandra; Hinterleitner, Clemens; Malenke, Elke; Bugl, Stefanie; Wirths, Stefan; Müller, Martin R; Schulze-Osthoff, Klaus; Aulitzky, Walter E; Kopp, Hans-Georg; Essmann, Frank.
Affiliation
  • Muenchow A; Department of Molecular Oncology, Robert Bosch Centre for Tumor Diseases and Robert-Bosch-Hospital, Auerbachstr. 110, 70376, Stuttgart, Germany.
  • Weller S; Dr. Margarete-Fischer-Bosch Institute of Clinical Pharmacology and University of Tübingen, Auerbachstr. 112, 70376, Stuttgart, Germany.
  • Hinterleitner C; Department of Internal Medicine II, University of Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany.
  • Malenke E; University Children's Hospital Tübingen, Hoppe-Seyler-Str. 1, 72076, Tübingen, Germany.
  • Bugl S; Department of Internal Medicine II, University of Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany.
  • Wirths S; Department of Internal Medicine II, University of Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany.
  • Müller MR; Department of Internal Medicine II, University of Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany.
  • Schulze-Osthoff K; Department of Oncology, Hematology and Immunology, Klinikum Siloah, 30449, Hannover, Germany.
  • Aulitzky WE; Department of Molecular Medicine, Interfaculty Institute for Biochemistry, University of Tübingen, Hoppe-Seyler-Str. 4, 72076, Tübingen, Germany.
  • Kopp HG; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  • Essmann F; Department of Hematology, Oncology and Palliative Medicine, Robert-Bosch-Hospital, Auberbachstr. 110, 70376, Stuttgart, Germany.
Cell Death Dis ; 11(8): 701, 2020 08 24.
Article in En | MEDLINE | ID: mdl-32839432
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sarcoma / Sulfonamides / Bridged Bicyclo Compounds, Heterocyclic / Bortezomib Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Cell Death Dis Year: 2020 Type: Article Affiliation country: Germany
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sarcoma / Sulfonamides / Bridged Bicyclo Compounds, Heterocyclic / Bortezomib Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Cell Death Dis Year: 2020 Type: Article Affiliation country: Germany