Epidemiologic, Phenotypic, and Structural Characterization of Aminoglycoside-Resistance Gene <i>aac(3)-IV</i>.

Plattner, Michel; Gysin, Marina; Haldimann, Klara; Becker, Katja; Hobbie, Sven N

Epidemiologic, Phenotypic, and Structural Characterization of Aminoglycoside-Resistance Gene aac(3)-IV.

Plattner, Michel; Gysin, Marina; Haldimann, Klara; Becker, Katja; Hobbie, Sven N.

Affiliation

Plattner M; Institute of Medical Microbiology, University of Zurich, 8006 Zurich, Switzerland.
Gysin M; Institute of Medical Microbiology, University of Zurich, 8006 Zurich, Switzerland.
Haldimann K; Institute of Medical Microbiology, University of Zurich, 8006 Zurich, Switzerland.
Becker K; Institute of Medical Microbiology, University of Zurich, 8006 Zurich, Switzerland.
Hobbie SN; Institute of Medical Microbiology, University of Zurich, 8006 Zurich, Switzerland.

Int J Mol Sci ; 21(17)2020 Aug 25.

Article in En | MEDLINE | ID: mdl-32854436

Subject(s)

Acetyltransferases/genetics; Aminoglycosides/pharmacology; Anti-Bacterial Agents/pharmacology; Drug Resistance, Bacterial; Gram-Negative Bacteria/genetics; Gram-Negative Bacterial Infections/microbiology; Acetyltransferases/chemistry; Acetyltransferases/metabolism; Aminoglycosides/chemistry; Anti-Bacterial Agents/chemistry; Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Carbapenems/pharmacology; Catalytic Domain; Databases, Genetic; Genome, Bacterial/drug effects; Gram-Negative Bacteria/drug effects; Gram-Negative Bacterial Infections/drug therapy; Humans; Methyltransferases/chemistry; Methyltransferases/genetics; Methyltransferases/metabolism; Molecular Epidemiology; Mutagenesis, Site-Directed; Nebramycin/analogs & derivatives; Nebramycin/pharmacology; Standard of Care; Structure-Activity Relationship

Key words

aac(3)-IV; acetyltransferase; aminoglycosides; antimicrobial resistance; apramycin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetyltransferases / Gram-Negative Bacterial Infections / Drug Resistance, Bacterial / Gram-Negative Bacteria / Aminoglycosides / Anti-Bacterial Agents Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: Switzerland

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