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Alum triggers infiltration of human neutrophils ex vivo and causes lysosomal destabilization and mitochondrial membrane potential-dependent NET-formation.
Reithofer, Manuel; Karacs, Jasmine; Strobl, Johanna; Kitzmüller, Claudia; Polak, Dominika; Seif, Katharina; Kamalov, Meder; Becker, Christian F W; Greiner, Georg; Schmetterer, Klaus; Stary, Georg; Bohle, Barbara; Jahn-Schmid, Beatrice.
Affiliation
  • Reithofer M; Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
  • Karacs J; Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
  • Strobl J; Department of Dermatology, Medical University of Vienna, Vienna, Austria.
  • Kitzmüller C; Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
  • Polak D; Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
  • Seif K; Department of Surgery, Medical University of Vienna, Vienna, Austria.
  • Kamalov M; Institute of Biological Chemistry, Department of Chemistry, University of Vienna, Vienna, Austria.
  • Becker CFW; Institute of Biological Chemistry, Department of Chemistry, University of Vienna, Vienna, Austria.
  • Greiner G; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
  • Schmetterer K; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
  • Stary G; Department of Dermatology, Medical University of Vienna, Vienna, Austria.
  • Bohle B; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
  • Jahn-Schmid B; CeMM Research Center for Molecular Medicine, Vienna, Austria.
FASEB J ; 34(10): 14024-14041, 2020 10.
Article in En | MEDLINE | ID: mdl-32860638
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adjuvants, Immunologic / Neutrophil Infiltration / Membrane Potential, Mitochondrial / Aluminum Hydroxide / Extracellular Traps / Lysosomes / Neutrophils Type of study: Etiology_studies Limits: Humans Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2020 Type: Article Affiliation country: Austria
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adjuvants, Immunologic / Neutrophil Infiltration / Membrane Potential, Mitochondrial / Aluminum Hydroxide / Extracellular Traps / Lysosomes / Neutrophils Type of study: Etiology_studies Limits: Humans Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2020 Type: Article Affiliation country: Austria