Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication.

Klann, Kevin; Bojkova, Denisa; Tascher, Georg; Ciesek, Sandra; Münch, Christian; Cinatl, Jindrich

Klann, Kevin; Bojkova, Denisa; Tascher, Georg; Ciesek, Sandra; Münch, Christian; Cinatl, Jindrich.

Affiliation

Klann K; Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany.
Bojkova D; Institute of Medical Virology, University Hospital Frankfurt, Frankfurt am Main, Germany.
Tascher G; Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany.
Ciesek S; Institute of Medical Virology, University Hospital Frankfurt, Frankfurt am Main, Germany; German Centre for Infection Research (DZIF), External partner site, Frankfurt, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch Translational Medicine and Pharmacology, Fran
Münch C; Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany; Frankfurt Cancer Institute and Cardio-Pulmonary Institute, Frankfurt am Main, Germany. Electronic address: ch.muench@em.uni-frankfurt.de.
Cinatl J; Institute of Medical Virology, University Hospital Frankfurt, Frankfurt am Main, Germany. Electronic address: cinatl@em.uni-frankfurt.de.

Mol Cell ; 80(1): 164-174.e4, 2020 10 01.

Article in En | MEDLINE | ID: mdl-32877642

Subject(s)

Antiviral Agents/therapeutic use; Betacoronavirus/drug effects; Mitogen-Activated Protein Kinases/genetics; Phosphatidylinositol 3-Kinase/genetics; Receptors, Growth Factor/genetics; Viral Proteins/genetics; Adrenal Cortex Hormones/therapeutic use; Angiotensin-Converting Enzyme Inhibitors/therapeutic use; Antibodies, Neutralizing/therapeutic use; Betacoronavirus/immunology; Betacoronavirus/pathogenicity; Caco-2 Cells; Gene Expression Regulation; Host-Pathogen Interactions/drug effects; Host-Pathogen Interactions/genetics; Humans; Mitogen-Activated Protein Kinases/antagonists & inhibitors; Mitogen-Activated Protein Kinases/metabolism; Phosphatidylinositol 3-Kinase/metabolism; Phosphoproteins/antagonists & inhibitors; Phosphoproteins/genetics; Phosphoproteins/metabolism; Phosphorylation; Receptors, Growth Factor/antagonists & inhibitors; Receptors, Growth Factor/metabolism; SARS-CoV-2; Signal Transduction; Viral Proteins/antagonists & inhibitors; Viral Proteins/metabolism; Virus Replication/drug effects

Key words

COVID-19; PI3K; RAS; SARS-CoV-2; TMT; drug repurposing; phosphoproteomics; proteomics; signaling; viral replication

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Viral Proteins / Receptors, Growth Factor / Mitogen-Activated Protein Kinases / Phosphatidylinositol 3-Kinase / Betacoronavirus Type of study: Prognostic_studies Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2020 Type: Article Affiliation country: Germany

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