Congenital Zika Virus Infection: a Review with Emphasis on the Spectrum of Brain Abnormalities.
Curr Neurol Neurosci Rep
; 20(11): 49, 2020 09 03.
Article
in En
| MEDLINE
| ID: mdl-32880775
ABSTRACT
PURPOSE OF REVIEW In 2016, the World Health Organization declared the Zika virus (ZIKV) outbreak a Public Health Emergency of International Concern following a cluster of associated neurological disorders and neonatal malformations. Our aim is to review the clinical and neuroimaging findings seen in congenital Zika syndrome. RECENT FINDINGS:
ZIKV injures neural progenitor cells in the hippocampus, a brain region important for learning, memory, cognition, and emotion/stress response. Positron emission tomography has revealed global neuroinflammation in ZIKV infection in animal models. Congenital Zika syndrome is associated with a spectrum of brain abnormalities, including microcephaly, parenchymal calcifications, malformations of cortical development and defective neuronal migration, corpus callosum abnormalities, ventriculomegaly, and brainstem and cerebellar abnormalities.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Complications, Infectious
/
Zika Virus
/
Zika Virus Infection
/
Microcephaly
Type of study:
Prognostic_studies
Limits:
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Curr Neurol Neurosci Rep
Journal subject:
NEUROLOGIA
Year:
2020
Type:
Article
Affiliation country:
Brazil