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FcγRIIB engagement drives agonistic activity of Fc-engineered αOX40 antibody to stimulate human tumor-infiltrating T cells.
Campos Carrascosa, Lucia; van Beek, Adriaan A; de Ruiter, Valeska; Doukas, Michail; Wei, Jie; Fisher, Timothy S; Ching, Keith; Yang, Wenjing; van Loon, Karlijn; Boor, Patrick P C; Rakké, Yannick S; Noordam, Lisanne; Doornebosch, Pascal; Grünhagen, Dirk; Verhoef, Kees; Polak, Wojciech G; IJzermans, Jan N M; Ni, Irene; Yeung, Yik Andy; Salek-Ardakani, Shahram; Sprengers, Dave; Kwekkeboom, Jaap.
Affiliation
  • Campos Carrascosa L; Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.
  • van Beek AA; Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.
  • de Ruiter V; Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.
  • Doukas M; Pathology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.
  • Wei J; Pfizer Cancer Immunology Discovery, Pfizer Inc, San Diego, California, USA.
  • Fisher TS; Pfizer Cancer Immunology Discovery, Pfizer Inc, San Diego, California, USA.
  • Ching K; Pfizer Cancer Immunology Discovery, Pfizer Inc, San Diego, California, USA.
  • Yang W; Pfizer Cancer Immunology Discovery, Pfizer Inc, San Diego, California, USA.
  • van Loon K; Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.
  • Boor PPC; Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.
  • Rakké YS; Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.
  • Noordam L; Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.
  • Doornebosch P; Surgery, IJsselland Hospital, Capelle aan den IJssel, Netherlands.
  • Grünhagen D; Surgery, Erasmus MC-University Medical Center, Rotterdam, Netherlands.
  • Verhoef K; Surgery, Erasmus MC-University Medical Center, Rotterdam, Netherlands.
  • Polak WG; Surgery, Erasmus MC-University Medical Center, Rotterdam, Netherlands.
  • IJzermans JNM; Surgery, Erasmus MC-University Medical Center, Rotterdam, Netherlands.
  • Ni I; Pfizer Cancer Immunology Discovery, Pfizer Inc, San Diego, California, USA.
  • Yeung YA; Pfizer Cancer Immunology Discovery, Pfizer Inc, San Diego, California, USA.
  • Salek-Ardakani S; Pfizer Cancer Immunology Discovery, Pfizer Inc, San Diego, California, USA.
  • Sprengers D; Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.
  • Kwekkeboom J; Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands j.kwekkeboom@erasmusmc.nl.
J Immunother Cancer ; 8(2)2020 09.
Article in En | MEDLINE | ID: mdl-32900860
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Lymphocytes, Tumor-Infiltrating / Receptors, OX40 / Immunotherapy Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Immunother Cancer Year: 2020 Type: Article Affiliation country: Netherlands
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Lymphocytes, Tumor-Infiltrating / Receptors, OX40 / Immunotherapy Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Immunother Cancer Year: 2020 Type: Article Affiliation country: Netherlands