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Decrease of core 2 O-glycans on synovial lubricin in osteoarthritis reduces galectin-3 mediated crosslinking.
Flowers, Sarah A; Thomsson, Kristina A; Ali, Liaqat; Huang, Shan; Mthembu, Yolanda; Regmi, Suresh C; Holgersson, Jan; Schmidt, Tannin A; Rolfson, Ola; Björkman, Lena I; Sundqvist, Martina; Karlsson-Bengtsson, Anna; Jay, Gregory D; Eisler, Thomas; Krawetz, Roman; Karlsson, Niclas G.
Affiliation
  • Flowers SA; Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Thomsson KA; Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Ali L; Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Huang S; Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Mthembu Y; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Regmi SC; Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.
  • Holgersson J; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Schmidt TA; Biomedical Engineering Department, University of Connecticut Health Center, Farmington, Connecticut, USA.
  • Rolfson O; Department of Orthopaedics, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Björkman LI; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Sundqvist M; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Karlsson-Bengtsson A; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Chalmers University of Technology, Gothenburg, Sweden.
  • Jay GD; Department of Emergency Medicine, Warren Alpert Medical School and Division of Biomedical Engineering, School of Engineering, Brown University, Providence, Rhode Island, USA.
  • Eisler T; Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden.
  • Krawetz R; Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada.
  • Karlsson NG; Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: niclas.karlsson@medkem.gu.se.
J Biol Chem ; 295(47): 16023-16036, 2020 11 20.
Article in En | MEDLINE | ID: mdl-32928962
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Proteoglycans / Synovial Membrane / Blood Proteins / Galectins Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: J Biol Chem Year: 2020 Type: Article Affiliation country: Sweden
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Proteoglycans / Synovial Membrane / Blood Proteins / Galectins Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: J Biol Chem Year: 2020 Type: Article Affiliation country: Sweden