Your browser doesn't support javascript.
loading
Acute interstitial nephritis and nephrogenic diabetes insipidus following treatment with sulfamethoxazole-trimethoprim and temozolomide.
Athavale, Akshay; Morris, Jack; Jardine, Meg; Gallagher, Martin; Sen, Shaundeep; Ritchie, Angus; Wang, Amanda Y.
Affiliation
  • Athavale A; Department of Renal Medicine, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
  • Morris J; Concord Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
  • Jardine M; Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
  • Gallagher M; Department of Renal Medicine, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
  • Sen S; Concord Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
  • Ritchie A; Renal and Metabolic Division, The George Institute for Global Health, Sydney, New South Wales, Australia.
  • Wang AY; Department of Renal Medicine, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
Nephrology (Carlton) ; 26(1): 12-14, 2021 Jan.
Article in En | MEDLINE | ID: mdl-32935422
ABSTRACT
We report a case of acute interstitial nephritis with associated nephrogenic diabetes insipidus in a patient treated with temozolomide and sulfamethoxazole-trimethoprim for glioblastoma multiforme. Kidney biopsy demonstrated focal tubulointerstitial change with tubular dilatation, epithelial change and interstitial inflammation. The patient's kidney function improved with cessation of sulfamethoxazole-trimethoprim and treatment with hydrochlorothiazide for nephrogenic diabetes insipidus. Recommencement of temozolomide did not result in further deterioration in kidney function. In this case report, we discuss the novel association between sulfamethoxazole-trimethoprim-induced acute interstitial nephritis and nephrogenic diabetes insipidus, and suggest possible mechanisms involved.
Subject(s)
Key words
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Trimethoprim, Sulfamethoxazole Drug Combination / Glioblastoma / Acute Kidney Injury / Hydrochlorothiazide / Nephritis, Interstitial Type of study: Diagnostic_studies / Etiology_studies Limits: Humans / Male / Middle aged Language: En Journal: Nephrology (Carlton) Journal subject: NEFROLOGIA Year: 2021 Type: Article Affiliation country: Australia
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Trimethoprim, Sulfamethoxazole Drug Combination / Glioblastoma / Acute Kidney Injury / Hydrochlorothiazide / Nephritis, Interstitial Type of study: Diagnostic_studies / Etiology_studies Limits: Humans / Male / Middle aged Language: En Journal: Nephrology (Carlton) Journal subject: NEFROLOGIA Year: 2021 Type: Article Affiliation country: Australia