Disorder in a two-domain neuronal Ca<sup>2+</sup>-binding protein regulates domain stability and dynamics using ligand mimicry.

Staby, Lasse; Kemplen, Katherine R; Stein, Amelie; Ploug, Michael; Clarke, Jane; Skriver, Karen; Heidarsson, Pétur O; Kragelund, Birthe B

Disorder in a two-domain neuronal Ca²⁺-binding protein regulates domain stability and dynamics using ligand mimicry.

Staby, Lasse; Kemplen, Katherine R; Stein, Amelie; Ploug, Michael; Clarke, Jane; Skriver, Karen; Heidarsson, Pétur O; Kragelund, Birthe B.

Affiliation

Staby L; Department of Biology, University of Copenhagen, Ole Maaloes Vej 5, 2200, Copenhagen, Denmark.
Kemplen KR; Department of Biology, University of Copenhagen, Ole Maaloes Vej 5, 2200, Copenhagen, Denmark.
Stein A; Department of Biology, University of Copenhagen, Ole Maaloes Vej 5, 2200, Copenhagen, Denmark.
Ploug M; Rigshospitalet, Finsen Laboratory, Ole Maaloes Vej 5, 2200, Copenhagen, Denmark.
Clarke J; Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaloes Vej 5, 2200, Copenhagen, Denmark.
Skriver K; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
Heidarsson PO; Department of Biology, University of Copenhagen, Ole Maaloes Vej 5, 2200, Copenhagen, Denmark.
Kragelund BB; Department of Biochemistry, Science Institute, University of Iceland, 107, Reykjavík, Iceland.

Cell Mol Life Sci ; 78(5): 2263-2278, 2021 Mar.

Article in En | MEDLINE | ID: mdl-32936312

Subject(s)

Carrier Proteins/chemistry; Intrinsically Disordered Proteins/chemistry; Neuronal Calcium-Sensor Proteins/chemistry; Neuropeptides/chemistry; Protein Domains; Amino Acid Sequence; Binding Sites/genetics; Carrier Proteins/genetics; Carrier Proteins/metabolism; Humans; Hydrophobic and Hydrophilic Interactions; Intrinsically Disordered Proteins/genetics; Intrinsically Disordered Proteins/metabolism; Kinetics; Ligands; Models, Molecular; Mutation; Neuronal Calcium-Sensor Proteins/genetics; Neuronal Calcium-Sensor Proteins/metabolism; Neuropeptides/genetics; Neuropeptides/metabolism; Protein Stability; Thermodynamics

Key words

EF-hand; Frequenin; IDP; NCS-1; Orderdisorder interplay; Protein folding

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neuropeptides / Carrier Proteins / Neuronal Calcium-Sensor Proteins / Intrinsically Disordered Proteins / Protein Domains Limits: Humans Language: En Journal: Cell Mol Life Sci Journal subject: BIOLOGIA MOLECULAR Year: 2021 Type: Article Affiliation country: Denmark

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