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Comparison of ADAM19 and CUEDC2 expression in EHCC and their clinicopathological significance.
Xu, Shu; Huang, Shengfu; Li, Daiqiang; Zou, Qiong; Yuan, Yuan; Yang, Zhulin.
Affiliation
  • Xu S; Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, PR China.
  • Huang S; Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, PR China.
  • Li D; Department of Pathology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, PR China.
  • Zou Q; Department of Pathology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, PR China.
  • Yuan Y; Department of Pathology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, PR China.
  • Yang Z; Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, PR China.
Biomark Med ; 14(16): 1573-1584, 2020 11.
Article in En | MEDLINE | ID: mdl-32960074
Background: To evaluate the expression and clinicopathological significance of a disintegrin and metalloproteinases 19 (ADAM19) CUE domain containing protein 2 (CUEDC2) in extrahepatic cholangiocarcinoma (EHCC). Materials & methods: Immunostaining of ADAM19 and CUEDC2 was performed by EnVision immunohistochemistry in benign and malignant biliary tract tissues. Result: The expression of ADAM19 and CUEDC2 were significantly higher in EHCC (p < 0.05). ADAM19 expression was positive correlated with CUEDC2 expression in EHCC (p < 0.05). The overall survival time of those with positive expression of ADAM19 and CUEDC2 was lower (p < 0.001). Both positive expression of ADAM19 and CUEDC2 were independent prognostic factors in EHCC. Conclusion: ADAM19 and CUEDC2 have a positive correlation to the pathogenesis and dismal prognosis in EHCC.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cholangiocarcinoma / Adaptor Proteins, Signal Transducing / ADAM Proteins Type of study: Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Biomark Med Journal subject: BIOQUIMICA / MEDICINA Year: 2020 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cholangiocarcinoma / Adaptor Proteins, Signal Transducing / ADAM Proteins Type of study: Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Biomark Med Journal subject: BIOQUIMICA / MEDICINA Year: 2020 Type: Article