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Histomorphometric case-control study of subarticular osteophytes in patients with osteoarthritis of the hip.
Klose-Jensen, Rasmus; Nielsen, Andreas Wiggers; Hartlev, Louise Brøndt; Thomsen, Jesper Skovhus; Boel, Lene Warner Thorup; Laursen, Mogens; Keller, Kresten Krarup; Hauge, Ellen-Margrethe.
Affiliation
  • Klose-Jensen R; Department of Rheumatology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 45, 8200, Aarhus, Denmark. raujen@rm.dk.
  • Nielsen AW; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. raujen@rm.dk.
  • Hartlev LB; Department of Rheumatology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 45, 8200, Aarhus, Denmark.
  • Thomsen JS; Department of Rheumatology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 45, 8200, Aarhus, Denmark.
  • Boel LWT; Department of Clinical Medicine, Randers Regional Hospital, Randers, Denmark.
  • Laursen M; Department of Biomedicine - Anatomy, Aarhus University, Aarhus, Denmark.
  • Keller KK; Institute of Forensic Medicine, Aarhus University, Aarhus, Denmark.
  • Hauge EM; Orthopaedic Surgery Research Unit, Aalborg University Hospital, Aalborg, Denmark.
BMC Musculoskelet Disord ; 21(1): 653, 2020 Oct 06.
Article in En | MEDLINE | ID: mdl-33023570
ABSTRACT

OBJECTIVE:

The objective of this cross-sectional case-control study was to determine the prevalence and size of marginal and subarticular osteophytes in patients with osteoarthritis (OA), and to compare these to that of a control group.

DESIGN:

We investigated femoral heads from 25 patients with OA following hip replacement surgery, and 25 femoral heads from a control group obtained post-mortem. The area and boundary length of the femoral head, marginal osteophytes, and subarticular osteophytes were determined with histomorphometry. Marginal osteophytes were defined histologically as bony projections at the peripheral margin of the femoral head, while subarticular osteophytes were defined as areas of bone that expanded from the normal curvature of the femoral head into the articular cartilage.

RESULTS:

The prevalence of OA patients with marginal- and subarticular osteophytes were 100 and 84%, respectively. Whereas the prevalence of the participants in the control group with marginal- and subarticular osteophytes were 56 and 28%, respectively. The area and boundary length of marginal osteophytes was (median (Interquartile range)) 165.3mm2 (121.4-254.0) mm2 and 75.1 mm (50.8-99.3) mm for patients with OA compared to 0 mm2 (0-0.5) mm2 and 0 mm (0-0.5) mm for the control group (P <  0.001). For the subarticular osteophytes, the area and boundary length was 1.0 mm2 (0-4.4) mm2 and 1.4 mm (0-6.5) mm for patients with OA compared to 0 mm2 (0-0.5) mm2 and 0 mm (0-0.5) mm for the control group (P <  0.001).

CONCLUSION:

As expected, both marginal- and subarticular osteophytes at the femoral head, were more frequent and larger in patients with OA than in the control group. However, in the control group, subarticular osteophytes were more prevalent than expected from the minor osteophytic changes at the femoral head margin, which may suggest that subarticular osteophytes are an early degenerative phenomenon that ultimately might develop into clinical osteoarthritis.
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis, Hip / Cartilage, Articular / Osteophyte Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Humans Language: En Journal: BMC Musculoskelet Disord Journal subject: FISIOLOGIA / ORTOPEDIA Year: 2020 Type: Article Affiliation country: Denmark

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis, Hip / Cartilage, Articular / Osteophyte Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Humans Language: En Journal: BMC Musculoskelet Disord Journal subject: FISIOLOGIA / ORTOPEDIA Year: 2020 Type: Article Affiliation country: Denmark