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REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters.
Baum, Alina; Ajithdoss, Dharani; Copin, Richard; Zhou, Anbo; Lanza, Kathryn; Negron, Nicole; Ni, Min; Wei, Yi; Mohammadi, Kusha; Musser, Bret; Atwal, Gurinder S; Oyejide, Adelekan; Goez-Gazi, Yenny; Dutton, John; Clemmons, Elizabeth; Staples, Hilary M; Bartley, Carmen; Klaffke, Benjamin; Alfson, Kendra; Gazi, Michal; Gonzalez, Olga; Dick, Edward; Carrion, Ricardo; Pessaint, Laurent; Porto, Maciel; Cook, Anthony; Brown, Renita; Ali, Vaneesha; Greenhouse, Jack; Taylor, Tammy; Andersen, Hanne; Lewis, Mark G; Stahl, Neil; Murphy, Andrew J; Yancopoulos, George D; Kyratsous, Christos A.
Affiliation
  • Baum A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Ajithdoss D; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Copin R; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Zhou A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Lanza K; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Negron N; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Ni M; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Wei Y; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Mohammadi K; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Musser B; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Atwal GS; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Oyejide A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Goez-Gazi Y; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.
  • Dutton J; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.
  • Clemmons E; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.
  • Staples HM; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.
  • Bartley C; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.
  • Klaffke B; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.
  • Alfson K; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.
  • Gazi M; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.
  • Gonzalez O; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.
  • Dick E; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.
  • Carrion R; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.
  • Pessaint L; BIOQUAL, Rockville, MD 20850, USA.
  • Porto M; BIOQUAL, Rockville, MD 20850, USA.
  • Cook A; BIOQUAL, Rockville, MD 20850, USA.
  • Brown R; BIOQUAL, Rockville, MD 20850, USA.
  • Ali V; BIOQUAL, Rockville, MD 20850, USA.
  • Greenhouse J; BIOQUAL, Rockville, MD 20850, USA.
  • Taylor T; BIOQUAL, Rockville, MD 20850, USA.
  • Andersen H; BIOQUAL, Rockville, MD 20850, USA.
  • Lewis MG; BIOQUAL, Rockville, MD 20850, USA.
  • Stahl N; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Murphy AJ; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Yancopoulos GD; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Kyratsous CA; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. christos.kyratsous@regeneron.com.
Science ; 370(6520): 1110-1115, 2020 11 27.
Article in En | MEDLINE | ID: mdl-33037066
ABSTRACT
An urgent global quest for effective therapies to prevent and treat coronavirus disease 2019 (COVID-19) is ongoing. We previously described REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987 and REGN10933) that targets nonoverlapping epitopes on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. In this report, we evaluate the in vivo efficacy of this antibody cocktail in both rhesus macaques, which may model mild disease, and golden hamsters, which may model more severe disease. We demonstrate that REGN-COV-2 can greatly reduce virus load in the lower and upper airways and decrease virus-induced pathological sequelae when administered prophylactically or therapeutically in rhesus macaques. Similarly, administration in hamsters limits weight loss and decreases lung titers and evidence of pneumonia in the lungs. Our results provide evidence of the therapeutic potential of this antibody cocktail.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antibodies, Neutralizing / Antibodies, Monoclonal, Humanized / COVID-19 Limits: Animals Language: En Journal: Science Year: 2020 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antibodies, Neutralizing / Antibodies, Monoclonal, Humanized / COVID-19 Limits: Animals Language: En Journal: Science Year: 2020 Type: Article Affiliation country: United States