SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation.

Ropa, James; Saha, Nirmalya; Hu, Hsiangyu; Peterson, Luke F; Talpaz, Moshe; Muntean, Andrew G

Ropa, James; Saha, Nirmalya; Hu, Hsiangyu; Peterson, Luke F; Talpaz, Moshe; Muntean, Andrew G.

Affiliation

Ropa J; University of Michigan Medical School.
Saha N; University of Michigan Medical School.
Hu H; University of Michigan Medical School.
Peterson LF; University of Michigan Medical School.
Talpaz M; University of Michigan School of Medicine and Comprehensive Cancer Center.
Muntean AG; University of Michigan Medical School.

Haematologica ; 105(9): 2273-2285, 2020 09 01.

Article in En | MEDLINE | ID: mdl-33054052

Subject(s)

Leukemia, Myeloid, Acute; Myeloid-Lymphoid Leukemia Protein; Animals; Histone-Lysine N-Methyltransferase/genetics; Histones/metabolism; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Humans; Leukemia, Myeloid, Acute/genetics; Lysine; Methylation; Mice; Myeloid-Lymphoid Leukemia Protein/genetics; Myeloid-Lymphoid Leukemia Protein/metabolism; Oncogene Proteins, Fusion/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Myeloid-Lymphoid Leukemia Protein Limits: Animals / Humans Language: En Journal: Haematologica Year: 2020 Type: Article

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