Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution- and Solid-State Investigations.
Angew Chem Int Ed Engl
; 60(5): 2500-2507, 2021 02 01.
Article
in En
| MEDLINE
| ID: mdl-33090592
ABSTRACT
Guanine quadruplex recognition has gained increasing attention, inspired by the growing awareness of the key roles played by these non-canonical nucleic acid architectures in cellular regulatory processes. We report here the solution and solid-state studies of a novel planar platinum(II) complex that is easily assembled from a simple ligand, and exhibits notable binding affinity for guanine quadruplex structures, while maintaining good selectivity for guanine quadruplex over duplex structures. A crystal structure of this ligand complexed with a telomeric quadruplex confirms double end-capping, with dimerization at the 5' interface.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Platinum
/
G-Quadruplexes
/
Guanine
Language:
En
Journal:
Angew Chem Int Ed Engl
Year:
2021
Type:
Article
Affiliation country:
Canada