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Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution- and Solid-State Investigations.
Miron, Caitlin E; van Staalduinen, Laura; Rangaswamy, Alana M; Chen, Mickey; Liang, Yushi; Jia, Zongchao; Mergny, Jean-Louis; Petitjean, Anne.
Affiliation
  • Miron CE; Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, ON, K7L 3N6, Canada.
  • van Staalduinen L; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, K7L 3N6, Canada.
  • Rangaswamy AM; Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, ON, K7L 3N6, Canada.
  • Chen M; Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, ON, K7L 3N6, Canada.
  • Liang Y; Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, ON, K7L 3N6, Canada.
  • Jia Z; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, K7L 3N6, Canada.
  • Mergny JL; Inserm U1212/CNRS UMR5320/Université de Bordeaux, Institut Européen de Chimie et Biologie, 2 rue Escarpit, 33607, Pessac, France.
  • Petitjean A; Laboratoire d'Optique et Biosciences, École Polytechnique, CNRS, INSERM, Institut Polytechnique de Paris, 91128, Palaiseau cedex, France.
Angew Chem Int Ed Engl ; 60(5): 2500-2507, 2021 02 01.
Article in En | MEDLINE | ID: mdl-33090592
ABSTRACT
Guanine quadruplex recognition has gained increasing attention, inspired by the growing awareness of the key roles played by these non-canonical nucleic acid architectures in cellular regulatory processes. We report here the solution and solid-state studies of a novel planar platinum(II) complex that is easily assembled from a simple ligand, and exhibits notable binding affinity for guanine quadruplex structures, while maintaining good selectivity for guanine quadruplex over duplex structures. A crystal structure of this ligand complexed with a telomeric quadruplex confirms double end-capping, with dimerization at the 5' interface.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Platinum / G-Quadruplexes / Guanine Language: En Journal: Angew Chem Int Ed Engl Year: 2021 Type: Article Affiliation country: Canada
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Platinum / G-Quadruplexes / Guanine Language: En Journal: Angew Chem Int Ed Engl Year: 2021 Type: Article Affiliation country: Canada