Infantile Inflammatory Myofibroblastic Tumor of Spleen.
Fetal Pediatr Pathol
; 41(3): 475-479, 2022 Jun.
Article
in En
| MEDLINE
| ID: mdl-33095087
ABSTRACT
Background:
Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm with unknown etiology and recurrent potential. They are widely reported in children and young adults. Nearly 50% of inflammatory myofibroblastic tumor harbor rearrangement in anaplastic lymphoma kinase (ALK) gene with the majority expressing ALK protein. ALK-negative IMTs harbor alteration in ROS1 gene in a subset of cases. Few reports have shown association of IMT with Epstein-Barr virus (EBV). Case report We report a case of IMT of the spleen in an 18-month-old infant presenting with abdominal distention and failure to thrive. Workup for ALK-1, ROS1, and EBV small-encoded RNA in-situ hybridization using immunohistochemistry was negative.Conclusions:
IMT can arise in an infant spleen.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Epstein-Barr Virus Infections
/
Granuloma, Plasma Cell
/
Neoplasms
Type of study:
Diagnostic_studies
Limits:
Adult
/
Child
/
Humans
/
Infant
Language:
En
Journal:
Fetal Pediatr Pathol
Journal subject:
PATOLOGIA
/
PEDIATRIA
Year:
2022
Type:
Article
Affiliation country:
India