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Preclinical Evaluation of a Novel TALEN Targeting CCR5 Confirms Efficacy and Safety in Conferring Resistance to HIV-1 Infection.
Romito, Marianna; Juillerat, Alexandre; Kok, Yik Lim; Hildenbeutel, Markus; Rhiel, Manuel; Andrieux, Geoffroy; Geiger, Johannes; Rudolph, Carsten; Mussolino, Claudio; Duclert, Aymeric; Metzner, Karin J; Duchateau, Philippe; Cathomen, Toni; Cornu, Tatjana I.
Affiliation
  • Romito M; Institute for Transfusion Medicine and Gene Therapy, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Freiburg, 79106, Germany.
  • Juillerat A; Faculty of Medicine, University of Freiburg, Freiburg, 79110, Germany.
  • Kok YL; Cellectis, Inc., New York, NY, 10016, USA.
  • Hildenbeutel M; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, 8091, Switzerland.
  • Rhiel M; Institute of Medical Virology, University of Zurich, Zurich, 8057, Switzerland.
  • Andrieux G; Institute for Transfusion Medicine and Gene Therapy, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Freiburg, 79106, Germany.
  • Geiger J; Faculty of Medicine, University of Freiburg, Freiburg, 79110, Germany.
  • Rudolph C; Institute for Transfusion Medicine and Gene Therapy, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Freiburg, 79106, Germany.
  • Mussolino C; Faculty of Medicine, University of Freiburg, Freiburg, 79110, Germany.
  • Duclert A; Faculty of Medicine, University of Freiburg, Freiburg, 79110, Germany.
  • Metzner KJ; Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Freiburg, 79110, Germany.
  • Duchateau P; German Cancer Consortium (DKTK), Freiburg, Germany and German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
  • Cathomen T; ethris GmbH, Planegg, 81249, Germany.
  • Cornu TI; ethris GmbH, Planegg, 81249, Germany.
Biotechnol J ; 16(1): e2000023, 2021 Jan.
Article in En | MEDLINE | ID: mdl-33103367
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / HIV-1 / Receptors, CCR5 / Transcription Activator-Like Effector Nucleases Limits: Humans Language: En Journal: Biotechnol J Journal subject: BIOTECNOLOGIA Year: 2021 Type: Article Affiliation country: Germany
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / HIV-1 / Receptors, CCR5 / Transcription Activator-Like Effector Nucleases Limits: Humans Language: En Journal: Biotechnol J Journal subject: BIOTECNOLOGIA Year: 2021 Type: Article Affiliation country: Germany