CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson's disease.

Galiano-Landeira, Jordi; Torra, Albert; Vila, Miquel; Bové, Jordi

Galiano-Landeira, Jordi; Torra, Albert; Vila, Miquel; Bové, Jordi.

Affiliation

Galiano-Landeira J; Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute, Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Barcelona, Catalonia, Spain.
Torra A; Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute, Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Barcelona, Catalonia, Spain.
Vila M; Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute, Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Barcelona, Catalonia, Spain.
Bové J; Department of Biochemistry and Molecular Biology, Autonomous University of Barcelona, Barcelona, Catalonia, Spain.

Brain ; 143(12): 3717-3733, 2020 12 01.

Article in En | MEDLINE | ID: mdl-33118032

Subject(s)

CD8-Positive T-Lymphocytes/pathology; Parkinson Disease/pathology; Substantia Nigra/pathology; Synucleinopathies/pathology; Aged; Aged, 80 and over; Brain/pathology; Cell Death; Cytokines/metabolism; Cytotoxins/metabolism; Disease Progression; Dopaminergic Neurons/pathology; Female; Granzymes/metabolism; Humans; Immunohistochemistry; Immunologic Surveillance; Lewy Body Disease/pathology; Male; Neurons/pathology; alpha-Synuclein/metabolism

Key words

Parkinson's disease; cytotoxic T lymphocyte; incidental Lewy body disease; tissue resident memory T cells; α-synuclein

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Substantia Nigra / CD8-Positive T-Lymphocytes / Synucleinopathies Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: Brain Year: 2020 Type: Article Affiliation country: Spain

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