Rev7 loss alters cisplatin response and increases drug efficacy in chemotherapy-resistant lung cancer.

Vassel, Faye-Marie; Bian, Ke; Walker, Graham C; Hemann, Michael T

Vassel, Faye-Marie; Bian, Ke; Walker, Graham C; Hemann, Michael T.

Affiliation

Vassel FM; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
Bian K; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
Walker GC; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; gwalker@mit.edu hemann@mit.edu.
Hemann MT; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; gwalker@mit.edu hemann@mit.edu.

Proc Natl Acad Sci U S A ; 117(46): 28922-28924, 2020 11 17.

Article in En | MEDLINE | ID: mdl-33144509

Subject(s)

Carcinoma, Non-Small-Cell Lung/drug therapy; Cisplatin/pharmacology; Lung Neoplasms/drug therapy; Mad2 Proteins/antagonists & inhibitors; Animals; Apoptosis/drug effects; Carcinoma, Non-Small-Cell Lung/genetics; Carcinoma, Non-Small-Cell Lung/metabolism; Cell Line, Tumor; DNA Damage; DNA Repair; DNA-Binding Proteins/metabolism; DNA-Directed DNA Polymerase/metabolism; Drug Resistance, Neoplasm; Humans; Lung Neoplasms/genetics; Lung Neoplasms/metabolism; Mad2 Proteins/metabolism; Mice; Mutagenesis; Tumor Cells, Cultured

Key words

Rev7; chemotherapy; cisplatin; lung cancer; translesion synthesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cisplatin / Carcinoma, Non-Small-Cell Lung / Mad2 Proteins / Lung Neoplasms Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Type: Article

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