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Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Kenyan blood donors.
Uyoga, Sophie; Adetifa, Ifedayo M O; Karanja, Henry K; Nyagwange, James; Tuju, James; Wanjiku, Perpetual; Aman, Rashid; Mwangangi, Mercy; Amoth, Patrick; Kasera, Kadondi; Ng'ang'a, Wangari; Rombo, Charles; Yegon, Christine; Kithi, Khamisi; Odhiambo, Elizabeth; Rotich, Thomas; Orgut, Irene; Kihara, Sammy; Otiende, Mark; Bottomley, Christian; Mupe, Zonia N; Kagucia, Eunice W; Gallagher, Katherine E; Etyang, Anthony; Voller, Shirine; Gitonga, John N; Mugo, Daisy; Agoti, Charles N; Otieno, Edward; Ndwiga, Leonard; Lambe, Teresa; Wright, Daniel; Barasa, Edwine; Tsofa, Benjamin; Bejon, Philip; Ochola-Oyier, Lynette I; Agweyu, Ambrose; Scott, J Anthony G; Warimwe, George M.
Affiliation
  • Uyoga S; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. suyoga@kemri-wellcome.org.
  • Adetifa IMO; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Karanja HK; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK.
  • Nyagwange J; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Tuju J; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Wanjiku P; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Aman R; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Mwangangi M; Ministry of Health, Government of Kenya, Nairobi, Kenya.
  • Amoth P; Ministry of Health, Government of Kenya, Nairobi, Kenya.
  • Kasera K; Ministry of Health, Government of Kenya, Nairobi, Kenya.
  • Ng'ang'a W; Ministry of Health, Government of Kenya, Nairobi, Kenya.
  • Rombo C; Presidential Policy and Strategy Unit, The Presidency, Government of Kenya, Nairobi, Kenya.
  • Yegon C; Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.
  • Kithi K; Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.
  • Odhiambo E; Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.
  • Rotich T; Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.
  • Orgut I; Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.
  • Kihara S; Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.
  • Otiende M; Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.
  • Bottomley C; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Mupe ZN; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK.
  • Kagucia EW; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Gallagher KE; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Etyang A; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Voller S; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK.
  • Gitonga JN; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Mugo D; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Agoti CN; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK.
  • Otieno E; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Ndwiga L; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Lambe T; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Wright D; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Barasa E; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Tsofa B; Nuffield Department of Medicine, Oxford University, Oxford, UK.
  • Bejon P; Nuffield Department of Medicine, Oxford University, Oxford, UK.
  • Ochola-Oyier LI; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Agweyu A; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Scott JAG; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
  • Warimwe GM; Nuffield Department of Medicine, Oxford University, Oxford, UK.
Science ; 371(6524): 79-82, 2021 01 01.
Article in En | MEDLINE | ID: mdl-33177105
ABSTRACT
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Africa is poorly described. The first case of SARS-CoV-2 in Kenya was reported on 12 March 2020, and an overwhelming number of cases and deaths were expected, but by 31 July 2020, there were only 20,636 cases and 341 deaths. However, the extent of SARS-CoV-2 exposure in the community remains unknown. We determined the prevalence of anti-SARS-CoV-2 immunoglobulin G among blood donors in Kenya in April-June 2020. Crude seroprevalence was 5.6% (174 of 3098). Population-weighted, test-performance-adjusted national seroprevalence was 4.3% (95% confidence interval, 2.9 to 5.8%) and was highest in urban counties Mombasa (8.0%), Nairobi (7.3%), and Kisumu (5.5%). SARS-CoV-2 exposure is more extensive than indicated by case-based surveillance, and these results will help guide the pandemic response in Kenya and across Africa.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Donors / Immunoglobulin G / COVID-19 / Antibodies, Viral Type of study: Risk_factors_studies Limits: Adolescent / Adult / Aged / Humans / Middle aged Country/Region as subject: Africa Language: En Journal: Science Year: 2021 Type: Article Affiliation country: Kenya
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Donors / Immunoglobulin G / COVID-19 / Antibodies, Viral Type of study: Risk_factors_studies Limits: Adolescent / Adult / Aged / Humans / Middle aged Country/Region as subject: Africa Language: En Journal: Science Year: 2021 Type: Article Affiliation country: Kenya