An actin depolymerizing agent 19,20-epoxycytochalasin Q of Xylaria sp. BCC 1067 enhanced antifungal action of azole drugs through ROS-mediated cell death in yeast.

Somboon, Pichayada; Soontorngun, Nitnipa

Somboon, Pichayada; Soontorngun, Nitnipa.

Affiliation

Somboon P; Division of Biochemical Technology, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
Soontorngun N; Division of Biochemical Technology, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkok, Thailand. Electronic address: nitnipa.soo@kmutt.ac.th.

Microbiol Res ; 243: 126646, 2021 Feb.

Article in En | MEDLINE | ID: mdl-33227681

Subject(s)

Actins/metabolism; Antifungal Agents/pharmacology; Azoles/pharmacology; Candida albicans/drug effects; Cytochalasins/pharmacology; Reactive Oxygen Species/metabolism; Saccharomyces cerevisiae/drug effects; Xylariales/chemistry; ATP-Binding Cassette Transporters/genetics; ATP-Binding Cassette Transporters/metabolism; Actins/chemistry; Antifungal Agents/chemistry; Antifungal Agents/metabolism; Candida albicans/genetics; Candida albicans/metabolism; Cytochalasins/metabolism; Drug Resistance, Fungal; Drug Synergism; Fungal Proteins/genetics; Fungal Proteins/metabolism; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Xylariales/metabolism

Key words

Actin; Antifungal; Cytochalasin; Drug resistance; Xylaria; Yeast

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saccharomyces cerevisiae / Xylariales / Azoles / Candida albicans / Actins / Reactive Oxygen Species / Cytochalasins / Antifungal Agents Language: En Journal: Microbiol Res Journal subject: MICROBIOLOGIA / SAUDE AMBIENTAL Year: 2021 Type: Article Affiliation country: Thailand

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