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Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis.
Massey, Veronica; Parrish, Austin; Argemi, Josepmaria; Moreno, Montserrat; Mello, Aline; García-Rocha, Mar; Altamirano, Jose; Odena, Gemma; Dubuquoy, Laurent; Louvet, Alexandre; Martinez, Carlos; Adrover, Anna; Affò, Silvia; Morales-Ibanez, Oriol; Sancho-Bru, Pau; Millán, Cristina; Alvarado-Tapias, Edilmar; Morales-Arraez, Dalia; Caballería, Juan; Mann, Jelena; Cao, Sheng; Sun, Zhaoli; Shah, Vijay; Cameron, Andrew; Mathurin, Phillipe; Snider, Natasha; Villanueva, Càndid; Morgan, Timothy R; Guinovart, Joan; Vadigepalli, Rajanikanth; Bataller, Ramon.
Affiliation
  • Massey V; Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition, and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, North Carolina.
  • Parrish A; Daniel Baugh Institute, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Argemi J; Department of Gastroenterology and Hepatology, Division of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Liver Unit, Clinica Universidad de Navarra. Hepatology Program, Center for Applied Medical Research, IdisNA, Pamplona, Spain.
  • Moreno M; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
  • Mello A; Department of Gastroenterology and Hepatology, Division of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
  • García-Rocha M; Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Barcelona, Spain.
  • Altamirano J; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain; Liver Unit, Internal Medicine Department, Hospital Universitari Vall d'Hebrón, Vall d'Hebrón Institut de Recerca, Barcelona, Spain.
  • Odena G; Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition, and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, North Carolina.
  • Dubuquoy L; Service des Maladies de l'appareil digestif, CHU Lille, Inserm LIRIC-UMR995, University of Lille, Lille, France.
  • Louvet A; Service des Maladies de l'appareil digestif, CHU Lille, Inserm LIRIC-UMR995, University of Lille, Lille, France.
  • Martinez C; Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Barcelona, Spain.
  • Adrover A; Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Barcelona, Spain.
  • Affò S; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
  • Morales-Ibanez O; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
  • Sancho-Bru P; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
  • Millán C; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
  • Alvarado-Tapias E; Department of Gastroenterology, Hospital Santa Creu i Sant Pau, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain.
  • Morales-Arraez D; Department of Gastroenterology and Hepatology, Division of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
  • Caballería J; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain; Liver Unit, Hospital Clínic, CIBER de Enfermedades Hepáticas y Digestivas, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain.
  • Mann J; Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom.
  • Cao S; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
  • Sun Z; Johns Hopkins School of Medicine, Department of Surgery and Transplant Biology Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland.
  • Shah V; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
  • Cameron A; Johns Hopkins School of Medicine, Department of Surgery and Transplant Biology Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland.
  • Mathurin P; Service des Maladies de l'appareil digestif, CHU Lille, Inserm LIRIC-UMR995, University of Lille, Lille, France.
  • Snider N; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina.
  • Villanueva C; Department of Gastroenterology, Hospital Santa Creu i Sant Pau, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain; Institut de Recerca, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Universitat Au
  • Morgan TR; Gastroenterology Services, VA Long Beach Healthcare, VA Long Beach Healthcare System, Long Beach, California.
  • Guinovart J; Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Barcelona, Spain.
  • Vadigepalli R; Daniel Baugh Institute, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Bataller R; Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition, and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, North Carolina; Department of Gastroenterology and Hepatology, Division of Medicine, University of Pittsburgh Medical Center, Pittsb
Gastroenterology ; 160(5): 1725-1740.e2, 2021 04.
Article in En | MEDLINE | ID: mdl-33309778
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Profiling / Hepatocytes / Energy Metabolism / Cell Dedifferentiation / Metabolomics / Glucose / Hepatitis, Alcoholic / Hexokinase / Liver Type of study: Clinical_trials Limits: Animals / Female / Humans / Male / Middle aged Country/Region as subject: America do norte / Europa Language: En Journal: Gastroenterology Year: 2021 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Profiling / Hepatocytes / Energy Metabolism / Cell Dedifferentiation / Metabolomics / Glucose / Hepatitis, Alcoholic / Hexokinase / Liver Type of study: Clinical_trials Limits: Animals / Female / Humans / Male / Middle aged Country/Region as subject: America do norte / Europa Language: En Journal: Gastroenterology Year: 2021 Type: Article