Antibiotics, Antineoplastic/pharmacology; Antineoplastic Agents, Phytogenic/pharmacology; Doxorubicin/pharmacology; Drug Delivery Systems; Paclitaxel/pharmacology; Polymers/chemistry; Animals; Antibiotics, Antineoplastic/chemistry; Antineoplastic Agents, Phytogenic/chemistry; Biocompatible Materials/chemical synthesis; Biocompatible Materials/chemistry; Cell Line; Cell Proliferation/drug effects; Cell Survival/drug effects; Cross-Linking Reagents/chemical synthesis; Cross-Linking Reagents/chemistry; Doxorubicin/chemistry; Drug Carriers/chemical synthesis; Drug Carriers/chemistry; Drug Screening Assays, Antitumor; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Mice; Molecular Structure; Paclitaxel/chemistry; Particle Size; Polymers/chemical synthesis; Surface Properties; Temperature; Tumor Microenvironment/drug effects