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SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species.
Moustaqil, Mehdi; Ollivier, Emma; Chiu, Hsin-Ping; Van Tol, Sarah; Rudolffi-Soto, Paulina; Stevens, Christian; Bhumkar, Akshay; Hunter, Dominic J B; Freiberg, Alexander N; Jacques, David; Lee, Benhur; Sierecki, Emma; Gambin, Yann.
Affiliation
  • Moustaqil M; EMBL Australia Node for Single Molecule Sciences, and School of Medical Sciences, Botany Road, The University of New South Wales, Sydney, Australia.
  • Ollivier E; EMBL Australia Node for Single Molecule Sciences, and School of Medical Sciences, Botany Road, The University of New South Wales, Sydney, Australia.
  • Chiu HP; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Van Tol S; Department of Microbiology and Immunology, Institute for Human Infections and Immunity, The University of Texas Medical Branch, Galveston, TX, USA.
  • Rudolffi-Soto P; EMBL Australia Node for Single Molecule Sciences, and School of Medical Sciences, Botany Road, The University of New South Wales, Sydney, Australia.
  • Stevens C; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Bhumkar A; EMBL Australia Node for Single Molecule Sciences, and School of Medical Sciences, Botany Road, The University of New South Wales, Sydney, Australia.
  • Hunter DJB; EMBL Australia Node for Single Molecule Sciences, and School of Medical Sciences, Botany Road, The University of New South Wales, Sydney, Australia.
  • Freiberg AN; Institute for Molecular Biosciences, The University of Queensland, St Lucia, Australia.
  • Jacques D; Department of Pathology, Institute for Human Infections and Immunity, The University of Texas Medical Branch, Galveston, TX, USA.
  • Lee B; EMBL Australia Node for Single Molecule Sciences, and School of Medical Sciences, Botany Road, The University of New South Wales, Sydney, Australia.
  • Sierecki E; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Gambin Y; EMBL Australia Node for Single Molecule Sciences, and School of Medical Sciences, Botany Road, The University of New South Wales, Sydney, Australia.
Emerg Microbes Infect ; 10(1): 178-195, 2021 Dec.
Article in En | MEDLINE | ID: mdl-33372854
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Intracellular Signaling Peptides and Proteins / Adaptor Proteins, Signal Transducing / Interferon Regulatory Factor-3 / Coronavirus 3C Proteases / Coronavirus Papain-Like Proteases Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Emerg Microbes Infect Year: 2021 Type: Article Affiliation country: Australia
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Intracellular Signaling Peptides and Proteins / Adaptor Proteins, Signal Transducing / Interferon Regulatory Factor-3 / Coronavirus 3C Proteases / Coronavirus Papain-Like Proteases Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Emerg Microbes Infect Year: 2021 Type: Article Affiliation country: Australia