Inhibition of interferon-signalling halts cancer-associated fibroblast-dependent protection of breast cancer cells from chemotherapy.

Broad, Robyn V; Jones, Stacey J; Teske, Melina C; Wastall, Laura M; Hanby, Andrew M; Thorne, James L; Hughes, Thomas A

Broad, Robyn V; Jones, Stacey J; Teske, Melina C; Wastall, Laura M; Hanby, Andrew M; Thorne, James L; Hughes, Thomas A.

Affiliation

Broad RV; School of Medicine, University of Leeds, Leeds, UK.
Jones SJ; School of Medicine, University of Leeds, Leeds, UK.
Teske MC; Department of Breast Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Wastall LM; School of Medicine, University of Leeds, Leeds, UK.
Hanby AM; Department of Histopathology, St. James's University Hospital, Leeds, UK.
Thorne JL; School of Medicine, University of Leeds, Leeds, UK.
Hughes TA; Department of Histopathology, St. James's University Hospital, Leeds, UK.

Br J Cancer ; 124(6): 1110-1120, 2021 03.

Article in En | MEDLINE | ID: mdl-33398063

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/pharmacology; Cancer-Associated Fibroblasts/pathology; Fibroblasts/pathology; Gene Expression Regulation, Neoplastic/drug effects; Interferon-beta/metabolism; Myxovirus Resistance Proteins/metabolism; Triple Negative Breast Neoplasms/pathology; Apoptosis; Biomarkers, Tumor/genetics; Biomarkers, Tumor/metabolism; Cancer-Associated Fibroblasts/drug effects; Cancer-Associated Fibroblasts/metabolism; Cell Proliferation; Coculture Techniques; Female; Fibroblasts/drug effects; Fibroblasts/metabolism; Humans; Interferon-beta/genetics; Myxovirus Resistance Proteins/genetics; Paracrine Communication; Prognosis; Transcriptome; Triple Negative Breast Neoplasms/drug therapy; Triple Negative Breast Neoplasms/genetics; Triple Negative Breast Neoplasms/metabolism; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Gene Expression Regulation, Neoplastic / Interferon-beta / Fibroblasts / Triple Negative Breast Neoplasms / Myxovirus Resistance Proteins / Cancer-Associated Fibroblasts Type of study: Prognostic_studies / Risk_factors_studies Limits: Female / Humans Language: En Journal: Br J Cancer Year: 2021 Type: Article Affiliation country: United kingdom

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