ALD, alcohol-related cirrhosis; ALT, alanine transaminase; APRI, AST to Platelet Ratio Index; AST, aspartate transaminase; BEC, biliary epithelial cells; BSA, bovine serum albumin; CT, computed tomography; DNL, de novo lipogenesis; FIB4, fibrosis-4; Fibrosis; Fructose; G/F, glucose/fructose; HSCs, hepatic stellate cells; HSECs, hepatic sinusoidal endothelial cells; HSQC, heteronuclear single quantum coherence; IGF, insulin-like growth factor; KHK, ketohexokinase; KO, knockout; LGLI, low glucose and insulin; Metabolism; NAFLD; NAFLD, non-alcoholic fatty liver disease; NASH; NASH, non-alcoholic steatohepatitis; NPCs, non-parenchymal cells; PBC, primary biliary cholangitis; PDGF, platelet-derived growth factor; PSC, primary sclerosing cholangitis; TG, triglyceride; TGFB, transforming growth factor beta; TIMP-1, Tissue Inhibitor of Matrix metalloproteinase-1; Treatment; WT, wild-type; aLMF, activated liver myofibroblasts