Control of thyroglobulin secretion in patients with ectopic thyroid gland.
Pediatr Res
; 23(3): 266-9, 1988 Mar.
Article
in En
| MEDLINE
| ID: mdl-3353172
ABSTRACT
Serum thyroglobulin (Tg) measurements were performed in 17 children with congenital hypothyroidism due to an ectopic thyroid gland before therapy and during follow-up. Data were analysed in four periods according to duration of therapy and compared to results obtained in a group of 51 normal children aged 1 month to 6 yr. At diagnosis serum Tg was higher than the mean normal value measured at a similar age. We observed a rapid and parallel decrease of both Tg and thyroid-stimulating hormone during the early weeks of therapy. However, Tg was always detectable in the serum of treated (euthyroid) patients. After 34 months of therapy serum Tg was 11.4 +/- 1 ng/ml, a value significantly different (p less than 0.001) from that obtained in normal controls of similar age (23.5 +/- 3 ng/ml). In nine treated children aged more than 2 yr, thyroid-stimulating hormone and Tg were increased after a brief period of decreased L-thyroxine dosage. These data indicate that ectopic thyroid tissue does not involute during thyroxine therapy and, in response to elevations of serum thyroid-stimulating hormone, can be stimulated to secrete Tg.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thyroglobulin
/
Thyroid Gland
/
Thyroxine
/
Choristoma
/
Hypothyroidism
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Child
/
Child, preschool
/
Humans
/
Infant
/
Newborn
Language:
En
Journal:
Pediatr Res
Year:
1988
Type:
Article
Affiliation country:
France