Connecting vascular aging and frailty in Alzheimer's disease.
Mech Ageing Dev
; 195: 111444, 2021 04.
Article
in En
| MEDLINE
| ID: mdl-33539904
ABSTRACT
Aging plays an important role in the etiology of the most common age-related diseases (ARDs), including Alzheimer's disease (AD). The increasing number of AD patients and the lack of disease-modifying drugs warranted intensive research to tackle the pathophysiological mechanisms underpinning AD development. Vascular aging/dysfunction is a common feature of almost all ARDs, including cardiovascular (CV) diseases, diabetes and AD. To this regard, interventions aimed at modifying CV outcomes are under extensive investigation for their pleiotropic role in ameliorating and slowing down cognitive impairment in middle-life and elderly individuals. Evidence from observational and clinical studies confirm the notion that the earlier the interventions are conducted, the most favorable are the effects on cognitive function. Therefore, epidemiological research should focus on the early detection of deviations from a healthy cognitive aging trajectory, through the stratification of adult individuals according to the rate of aging. Here, we review the interplay between vascular and cognitive dysfunctions associated with aging, to disentangle the complex mechanisms underpinning the development and progression of neurodegenerative disorders, with a specific focus on AD.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
/
Cognition
/
Alzheimer Disease
/
Cognitive Dysfunction
/
Vascular Remodeling
/
Frailty
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Screening_studies
Limits:
Humans
Language:
En
Journal:
Mech Ageing Dev
Year:
2021
Type:
Article
Affiliation country:
Italy