Apalutamide, darolutamide and enzalutamide in nonmetastatic castration-resistant prostate cancer: a meta-analysis.
Future Oncol
; 17(14): 1811-1823, 2021 May.
Article
in En
| MEDLINE
| ID: mdl-33543650
ABSTRACT
Aim:
Comparison of the efficacy/safety/health-related quality of life of apalutamide, enzalutamide and darolutamide in Phase III clinical trials involving patients with nonmetastatic castration-resistant prostate cancer was performed. Materials &methods:
Relevant studies were identified by searching PubMed as well as conference abstracts reporting updated overall survival. Three pivotal trials were identified, SPARTAN (apalutamide), PROSPER (enzalutamide) and ARAMIS (darolutamide), and form the basis of this analysis.Results:
All three drugs significantly prolonged metastasis-free survival, prostate-specific antigen response and overall survival versus placebo, and were generally well tolerated.Conclusion:
Drug selection will likely be influenced by tolerability/safety and other factors, such as the propensity for drug-drug interactions and the presence of comorbidities, that affect the risk-benefit balance in individual patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenylthiohydantoin
/
Pyrazoles
/
Thiohydantoins
/
Benzamides
/
Prostatic Neoplasms, Castration-Resistant
/
Nitriles
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Prognostic_studies
/
Systematic_reviews
Limits:
Humans
/
Male
Language:
En
Journal:
Future Oncol
Year:
2021
Type:
Article
Affiliation country:
France