Involvement of Cytokines and Hormones in the Development of Spermatogenesis In Vitro from Spermatogonial Cells of Cyclophosphamide-Treated Immature Mice.

Solomon, Ronnie; AbuMadighem, Ali; Kapelushnik, Joseph; Amano, Bat-Chen; Lunenfeld, Eitan; Huleihel, Mahmoud

Solomon, Ronnie; AbuMadighem, Ali; Kapelushnik, Joseph; Amano, Bat-Chen; Lunenfeld, Eitan; Huleihel, Mahmoud.

Affiliation

Solomon R; The Shraga Segal Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
AbuMadighem A; The Center of Advanced Research and Education in Reproduction (CARER), Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
Kapelushnik J; The Shraga Segal Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
Amano BC; The Center of Advanced Research and Education in Reproduction (CARER), Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
Lunenfeld E; The Center of Advanced Research and Education in Reproduction (CARER), Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
Huleihel M; Department of Pediatric Oncology and Department of Hematology, Soroka Medical Center, Beer Sheva 8410501, Israel.

Int J Mol Sci ; 22(4)2021 Feb 07.

Article in En | MEDLINE | ID: mdl-33562323

Subject(s)

Cyclophosphamide/toxicity; Cytokines/pharmacology; Hormones/pharmacology; Infertility, Male/pathology; Organ Size/drug effects; Spermatogenesis; Spermatogonia/pathology; Animals; DEAD-box RNA Helicases/genetics; DEAD-box RNA Helicases/metabolism; Glial Cell Line-Derived Neurotrophic Factor Receptors/genetics; Glial Cell Line-Derived Neurotrophic Factor Receptors/metabolism; In Vitro Techniques; Infertility, Male/chemically induced; Infertility, Male/metabolism; Integrin alpha6/genetics; Integrin alpha6/metabolism; Male; Mice; Mice, Inbred ICR; Mutagens/toxicity; Proto-Oncogene Proteins c-kit/genetics; Proto-Oncogene Proteins c-kit/metabolism; Spermatogonia/drug effects; Spermatogonia/metabolism; Tetraspanin 29/genetics; Tetraspanin 29/metabolism

Key words

chemotherapy; cyclophosphamide; cytokines; hormones; in vitro maturation of spermatogonial cells; male infertility; spermatogenesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organ Size / Spermatogenesis / Spermatogonia / Cytokines / Cyclophosphamide / Hormones / Infertility, Male Limits: Animals Language: En Journal: Int J Mol Sci Year: 2021 Type: Article Affiliation country: Israel

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