Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, ßPIX, impairs enterocyte proliferation, villus maturation, and mucosal defenses in mice.

Cheng, Kunrong; Larabee, Shannon M; Tolaymat, Mazen; Hanscom, Marie; Shang, Aaron C; Schledwitz, Alyssa; Hu, Shien; Drachenberg, Cinthia B; Zhan, Min; Chahdi, Ahmed; Raufman, Jean-Pierre

Cheng, Kunrong; Larabee, Shannon M; Tolaymat, Mazen; Hanscom, Marie; Shang, Aaron C; Schledwitz, Alyssa; Hu, Shien; Drachenberg, Cinthia B; Zhan, Min; Chahdi, Ahmed; Raufman, Jean-Pierre.

Affiliation

Cheng K; Veterans Affairs Maryland Healthcare System, Baltimore, Maryland.
Larabee SM; Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland.
Tolaymat M; Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Hanscom M; Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland.
Shang AC; Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland.
Schledwitz A; Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland.
Hu S; Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland.
Drachenberg CB; Veterans Affairs Maryland Healthcare System, Baltimore, Maryland.
Zhan M; Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland.
Chahdi A; Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland.
Raufman JP; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.

Am J Physiol Gastrointest Liver Physiol ; 320(4): G627-G643, 2021 04 01.

Article in En | MEDLINE | ID: mdl-33566751

Subject(s)

Cell Proliferation; Colitis/metabolism; Colon/metabolism; Enterocytes/metabolism; Intestinal Mucosa/metabolism; Microvilli/metabolism; Rho Guanine Nucleotide Exchange Factors/deficiency; Animals; Cells, Cultured; Colitis/chemically induced; Colitis/genetics; Colitis/pathology; Colon/pathology; Dextran Sulfate; Disease Models, Animal; Enterocytes/pathology; Female; Gene Deletion; Humans; Intestinal Mucosa/pathology; Intestine, Small/metabolism; Intestine, Small/pathology; Male; Mice, Inbred C57BL; Mice, Knockout; Microvilli/pathology; Organoids; Rho Guanine Nucleotide Exchange Factors/genetics; Rho Guanine Nucleotide Exchange Factors/metabolism; Signal Transduction; Tissue Culture Techniques; rho-Associated Kinases/metabolism

Key words

Rho-associated protein kinase; cell proliferation; dextran sodium sulfate colitis; intestinal epithelial cells; intestinal organoids; ß-catenin signaling

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis / Colon / Enterocytes / Cell Proliferation / Rho Guanine Nucleotide Exchange Factors / Intestinal Mucosa / Microvilli Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Am J Physiol Gastrointest Liver Physiol Journal subject: FISIOLOGIA / GASTROENTEROLOGIA Year: 2021 Type: Article

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