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Antinociceptive C19-diterpenoid alkaloids isolated from Aconitum pseudostapfianum.
Hu, Jiang; Li, Jia-Xun; Li, Qiang; Mao, Xia; Peng, Tian-Feng; Jin, Nian-Hua; Yin, Si; Tang, Ying.
Affiliation
  • Hu J; College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
  • Li JX; Tumor Hospital of Yunnan Province, The Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China.
  • Li Q; College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
  • Mao X; College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
  • Peng TF; College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
  • Jin NH; College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
  • Yin S; College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
  • Tang Y; Department of Quality Management, General Hospital of Northern Theater Command,, Shenyang, 110015, China.
J Asian Nat Prod Res ; 23(7): 637-643, 2021 Jul.
Article in En | MEDLINE | ID: mdl-33583282
ABSTRACT
Phytochemical investigation on the roots of Aconitum pseudostapfianum resulted in the isolation of three new aconitine-type C19-diterpenoid alkaloids, pseudostapines A-C (1-3). Their structures were determined by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, NOESY and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated alkaloids were tested in vivo for their antinociceptive potential. As a result, pseudostapine C (3) showed 2-fold more potent antinociceptive effect (ID50 = 60.3 µmol/kg) than the positive control drugs aspirin and acetaminophen.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aconitum / Diterpenes / Alkaloids Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2021 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aconitum / Diterpenes / Alkaloids Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2021 Type: Article Affiliation country: China