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Cannabidiol Ameliorates Cognitive Function via Regulation of IL-33 and TREM2 Upregulation in a Murine Model of Alzheimer's Disease.
Khodadadi, Hesam; Salles, Évila Lopes; Jarrahi, Abbas; Costigliola, Vincenzo; Khan, M B; Yu, Jack C; Morgan, John C; Hess, David C; Vaibhav, Kumar; Dhandapani, Krishnan M; Baban, Babak.
Affiliation
  • Khodadadi H; Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.
  • Salles ÉL; Center for Excellence in Research, Scholarship and Innovation, Dental College of Georgia, Augusta University, Augusta, GA, USA.
  • Jarrahi A; Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.
  • Costigliola V; Center for Excellence in Research, Scholarship and Innovation, Dental College of Georgia, Augusta University, Augusta, GA, USA.
  • Khan MB; Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • Yu JC; European Medical Association (EMA), Brussels, Belgium.
  • Morgan JC; Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • Hess DC; Department of Surgery, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • Vaibhav K; Parkinson's Foundation Center of Excellence, Movement Disorders, Program, Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • Dhandapani KM; Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • Baban B; Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA, USA.
J Alzheimers Dis ; 80(3): 973-977, 2021.
Article in En | MEDLINE | ID: mdl-33612548
ABSTRACT
There is a dire need for due innovative therapeutic modalities to improve outcomes of AD patients. In this study, we tested whether cannabidiol (CBD) improves outcomes in a translational model of familial AD and to investigate if CBD regulates interleukin (IL)-33 and triggering receptor expressed on myeloid cells 2 (TREM2), which are associated with improved cognitive function. CBD was administered to 5xFAD mice, which recapitulate early onset, familial AD. Behavioral tests and immunoassays were used to evaluate cognitive and motor outcomes. Our findings suggest that CBD treatment enhanced IL-33 and TREM2 expression, ameliorated the symptoms of AD, and retarded cognitive decline.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cannabidiol / Membrane Glycoproteins / Receptors, Immunologic / Cognition / Alzheimer Disease / Interleukin-33 Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Alzheimers Dis Journal subject: GERIATRIA / NEUROLOGIA Year: 2021 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cannabidiol / Membrane Glycoproteins / Receptors, Immunologic / Cognition / Alzheimer Disease / Interleukin-33 Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Alzheimers Dis Journal subject: GERIATRIA / NEUROLOGIA Year: 2021 Type: Article Affiliation country: United States