Self-assembly of multi-component mitochondrial nucleoids via phase separation.

Feric, Marina; Demarest, Tyler G; Tian, Jane; Croteau, Deborah L; Bohr, Vilhelm A; Misteli, Tom

Feric, Marina; Demarest, Tyler G; Tian, Jane; Croteau, Deborah L; Bohr, Vilhelm A; Misteli, Tom.

Affiliation

Feric M; National Cancer Institute, NIH, Bethesda, MD, USA.
Demarest TG; National Institute of General Medical Sciences, NIH, Bethesda, MD, USA.
Tian J; National Institute on Aging, NIH, Baltimore, MD, USA.
Croteau DL; National Institute on Aging, NIH, Baltimore, MD, USA.
Bohr VA; National Institute on Aging, NIH, Baltimore, MD, USA.
Misteli T; National Institute on Aging, NIH, Baltimore, MD, USA.

EMBO J ; 40(6): e107165, 2021 03 15.

Article in En | MEDLINE | ID: mdl-33619770

Subject(s)

DNA, Mitochondrial/genetics; Genome, Mitochondrial/genetics; Mitochondria/genetics; Progeria/pathology; Cell Line; Child; Child, Preschool; DNA-Binding Proteins/metabolism; HEK293 Cells; Humans; Mitochondrial Proteins/metabolism; Progeria/genetics; Transcription Factors/metabolism

Key words

TFAM; biomolecular condensate; genome organization; mitochondrial genome; phase separation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Progeria / DNA, Mitochondrial / Genome, Mitochondrial / Mitochondria Limits: Child / Child, preschool / Humans Language: En Journal: EMBO J Year: 2021 Type: Article Affiliation country: United States

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