Selections and screenings of DNA-encoded chemical libraries against enzyme and cellular targets.

Satz, Alexander L; Kuai, Letian; Peng, Xuanjia

Satz, Alexander L; Kuai, Letian; Peng, Xuanjia.

Affiliation

Satz AL; WuXi AppTec, Am Klopferspitz 19a, 82152 Martinsried, Germany. Electronic address: alex.satz@wuxiapptec.com.
Kuai L; WuXi AppTec, Am Klopferspitz 19a, 82152 Martinsried, Germany.
Peng X; WuXi AppTec, Am Klopferspitz 19a, 82152 Martinsried, Germany.

Bioorg Med Chem Lett ; 39: 127851, 2021 05 01.

Article in En | MEDLINE | ID: mdl-33631371

Subject(s)

DNA/pharmacology; Deoxyribonucleases/antagonists & inhibitors; Small Molecule Libraries/pharmacology; Animals; Cell Line; Deoxyribonucleases/metabolism; Drug Evaluation, Preclinical; Humans; Molecular Structure; Small Molecule Libraries/chemistry

Key words

Combinatorial chemistry; DNA encoded libraries; High throughput screening; Hit discovery; Medicinal chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / Deoxyribonucleases / Small Molecule Libraries Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Type: Article

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