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Design, synthesis and biological evaluations of diverse Michael acceptor-based phenazine hybrid molecules as TrxR1 inhibitors.
Zhong, Yucheng; Liu, Jing; Cheng, Xiangyu; Zhang, Hao; Zhang, Chunhua; Xia, Zhuolu; Wu, Zhongxi; Zhang, Lu; Zheng, Yuting; Gao, Zhanyu; Jiang, Zhidong; Wang, Zhixiang; Huang, Dechun; Lu, Yuanyuan; Jiang, Feng.
Affiliation
  • Zhong Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
  • Liu J; School of Engineering, China Pharmaceutical University, Nanjing 210009, China.
  • Cheng X; School of Engineering, China Pharmaceutical University, Nanjing 210009, China.
  • Zhang H; School of Engineering, China Pharmaceutical University, Nanjing 210009, China.
  • Zhang C; School of Engineering, China Pharmaceutical University, Nanjing 210009, China.
  • Xia Z; School of Engineering, China Pharmaceutical University, Nanjing 210009, China.
  • Wu Z; School of Engineering, China Pharmaceutical University, Nanjing 210009, China.
  • Zhang L; School of Engineering, China Pharmaceutical University, Nanjing 210009, China.
  • Zheng Y; School of Engineering, China Pharmaceutical University, Nanjing 210009, China.
  • Gao Z; School of Engineering, China Pharmaceutical University, Nanjing 210009, China.
  • Jiang Z; School of Engineering, China Pharmaceutical University, Nanjing 210009, China.
  • Wang Z; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; School of Engineering, China Pharmaceutical University, Nanjing 210009, China.
  • Huang D; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; School of Engineering, China Pharmaceutical University, Nanjing 210009, China.
  • Lu Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China. Electronic address: luyy@cpu.edu.cn.
  • Jiang F; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; School of Engineering, China Pharmaceutical University, Nanjing 210009, China. Electronic address: jiangfeng@cpu.edu.cn.
Bioorg Chem ; 109: 104736, 2021 04.
Article in En | MEDLINE | ID: mdl-33640630
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenazines / Drug Design / Enzyme Inhibitors / Thioredoxin Reductase 1 / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Chem Year: 2021 Type: Article Affiliation country: China
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenazines / Drug Design / Enzyme Inhibitors / Thioredoxin Reductase 1 / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Chem Year: 2021 Type: Article Affiliation country: China