Physiologically based pharmacokinetic/pharmacodynamic model for the prediction of morphine brain disposition and analgesia in adults and children.

Verscheijden, Laurens F M; Litjens, Carlijn H C; Koenderink, Jan B; Mathijssen, Ron H J; Verbeek, Marcel M; de Wildt, Saskia N; Russel, Frans G M

Verscheijden, Laurens F M; Litjens, Carlijn H C; Koenderink, Jan B; Mathijssen, Ron H J; Verbeek, Marcel M; de Wildt, Saskia N; Russel, Frans G M.

Affiliation

Verscheijden LFM; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.
Litjens CHC; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.
Koenderink JB; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, The Netherlands.
Mathijssen RHJ; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.
Verbeek MM; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
de Wildt SN; Departments of Neurology and Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
Russel FGM; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.

PLoS Comput Biol ; 17(3): e1008786, 2021 03.

Article in En | MEDLINE | ID: mdl-33661919

Subject(s)

Analgesics, Opioid; Brain/metabolism; Models, Biological; Morphine Derivatives; Morphine; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Adult; Age Factors; Analgesia; Analgesics, Opioid/administration & dosage; Analgesics, Opioid/blood; Analgesics, Opioid/pharmacokinetics; Blood-Brain Barrier/metabolism; Child; Child, Preschool; Computational Biology; Female; Humans; Infant, Newborn; Male; Morphine/administration & dosage; Morphine/blood; Morphine/pharmacokinetics; Morphine Derivatives/administration & dosage; Morphine Derivatives/blood; Morphine Derivatives/pharmacokinetics

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Analgesics, Opioid / Models, Biological / Morphine / Morphine Derivatives Type of study: Prognostic_studies / Risk_factors_studies Limits: Adult / Child / Child, preschool / Female / Humans / Male / Newborn Language: En Journal: PLoS Comput Biol Journal subject: BIOLOGIA / INFORMATICA MEDICA Year: 2021 Type: Article Affiliation country: Netherlands

Fulltext

XML

PubMed Links

Search on Google