FcRn is not the receptor mediating the transfer of serum IgG to colostrum in pigs.
Immunology
; 163(4): 448-459, 2021 08.
Article
in En
| MEDLINE
| ID: mdl-33738807
ABSTRACT
In contrast to humans or rabbits, in which maternal IgG is transmitted to offspring prenatally via the placenta or the yolk sac, large domestic animals such as pigs, cows and sheep transmit IgG exclusively through colostrum feeding after delivery. The extremely high IgG content in colostrum is absorbed by newborns via the small intestine. Although it is widely accepted that the neonatal Fc receptor, FcRn, is the receptor mediating IgG transfer across both the placenta and small intestine, it remains unclear whether FcRn also mediates serum IgG transfer across the mammary barrier to colostrum/milk, especially in large domestic animals. In this study, using a FcRn knockout pig model generated with a CRISPR-Cas9-based approach, we clearly demonstrate that FcRn is not responsible for the IgG transfer from serum to colostrum in pigs, although like in other mammals, it is involved in IgG homeostasis and mediates IgG absorption in the small intestine of newborns.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Placenta
/
Swine
/
Receptors, Fc
/
Histocompatibility Antigens Class I
/
Colostrum
/
Intestine, Small
Limits:
Animals
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Immunology
Year:
2021
Type:
Article
Affiliation country:
China