Adiponectin regulates osteocytic MLO-Y4 cell apoptosis in a high-glucose environment through the AMPK/FoxO3a signaling pathway.

Zeng, Yuanyuan; Liang, Hengxing; Guo, Yue; Feng, Yunzhi; Yao, Qianqian

Zeng, Yuanyuan; Liang, Hengxing; Guo, Yue; Feng, Yunzhi; Yao, Qianqian.

Affiliation

Zeng Y; Center of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Liang H; Department of Stomatology, Shaoyang Central Hospital, Shaoyang, Hunan, China.
Guo Y; Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Feng Y; Center of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yao Q; Center of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

J Cell Physiol ; 236(10): 7088-7096, 2021 10.

Article in En | MEDLINE | ID: mdl-33792917

Subject(s)

AMP-Activated Protein Kinases/metabolism; Adiponectin/pharmacology; Apoptosis/drug effects; Forkhead Box Protein O3/metabolism; Glucose/toxicity; Osteocytes/drug effects; Animals; Apoptosis Regulatory Proteins/genetics; Apoptosis Regulatory Proteins/metabolism; Cell Line; Cell Proliferation/drug effects; Mice; Osteocytes/enzymology; Osteocytes/pathology; Phosphorylation; Reactive Oxygen Species/metabolism; Signal Transduction

Key words

AMPK; FoxO3A; adiponectin; apoptosis; osteocytes

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteocytes / Apoptosis / Adiponectin / AMP-Activated Protein Kinases / Forkhead Box Protein O3 / Glucose Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Cell Physiol Year: 2021 Type: Article Affiliation country: China

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