Synthesis, Molecular Docking Studies and In Silico ADMET Screening of New Heterocycles Linked Thiazole Conjugates as Potent Anti-Hepatic Cancer Agents.

Rashdan, Huda R M; El-Naggar, Mohamed; Abdelmonsef, Aboubakr H

Rashdan, Huda R M; El-Naggar, Mohamed; Abdelmonsef, Aboubakr H.

Affiliation

Rashdan HRM; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12622, Egypt.
El-Naggar M; Chemistry Department, Faculty of Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates.
Abdelmonsef AH; Chemistry Department, Faculty of Science, South Valley University, Qena 83523, Egypt.

Molecules ; 26(6)2021 Mar 18.

Article in En | MEDLINE | ID: mdl-33803823

Subject(s)

Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Liver Neoplasms/drug therapy; Thiazoles/chemistry; Thiazoles/pharmacology; Animals; Antineoplastic Agents/chemical synthesis; BALB 3T3 Cells; Binding Sites; Computer Simulation; Drug Screening Assays, Antitumor; Hep G2 Cells; Heterocyclic Compounds/chemical synthesis; Heterocyclic Compounds/chemistry; Heterocyclic Compounds/pharmacology; Humans; Mice; Molecular Docking Simulation; Structure-Activity Relationship; Thiazoles/chemical synthesis; rho GTP-Binding Proteins/chemistry

Key words

1,2,3-triazoles; Rho6 protein; anti-hepatic cancer agents; thiazoles

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiazoles / Liver Neoplasms / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Type: Article Affiliation country: Egypt

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