Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET.

Neijssen, Joost; Cardoso, Rosa M F; Chevalier, Kristen M; Wiegman, Luus; Valerius, Thomas; Anderson, G Mark; Moores, Sheri L; Schuurman, Janine; Parren, Paul W H I; Strohl, William R; Chiu, Mark L

Neijssen, Joost; Cardoso, Rosa M F; Chevalier, Kristen M; Wiegman, Luus; Valerius, Thomas; Anderson, G Mark; Moores, Sheri L; Schuurman, Janine; Parren, Paul W H I; Strohl, William R; Chiu, Mark L.

Affiliation

Neijssen J; Genmab, Utrecht, The Netherlands.
Cardoso RMF; Janssen Research & Development, Spring House, Pennsylvania, USA.
Chevalier KM; Janssen Research & Development, Spring House, Pennsylvania, USA.
Wiegman L; Genmab, Utrecht, The Netherlands.
Valerius T; Section for Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Christian Albrechts University and University Hospital Schleswig-Holstein, Kiel, Germany.
Anderson GM; Janssen Research & Development, Spring House, Pennsylvania, USA.
Moores SL; Janssen Research & Development, Spring House, Pennsylvania, USA.
Schuurman J; Genmab, Utrecht, The Netherlands.
Parren PWHI; Genmab, Utrecht, The Netherlands.
Strohl WR; Janssen Research & Development, Spring House, Pennsylvania, USA.
Chiu ML; Janssen Research & Development, Spring House, Pennsylvania, USA. Electronic address: markchiu03@gmail.com.

J Biol Chem ; 296: 100641, 2021.

Article in En | MEDLINE | ID: mdl-33839159

Subject(s)

Antibodies, Bispecific/pharmacology; Carcinoma, Non-Small-Cell Lung/drug therapy; Drug Discovery; Lung Neoplasms/drug therapy; Proto-Oncogene Proteins c-met/antagonists & inhibitors; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung/immunology; Carcinoma, Non-Small-Cell Lung/metabolism; Carcinoma, Non-Small-Cell Lung/pathology; Cell Proliferation; ErbB Receptors/antagonists & inhibitors; ErbB Receptors/immunology; Female; Humans; Lung Neoplasms/immunology; Lung Neoplasms/metabolism; Lung Neoplasms/pathology; Mice; Proto-Oncogene Proteins c-met/immunology; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

Key words

EGFR exon 20 insertion; MET amplification; amivantamab; bispecific anti-EGFR×MET antibody; combinatorial screening; crystal structure; epitope mapping; nonsmall cell lung cancer (NSCLC)

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antibodies, Bispecific / Carcinoma, Non-Small-Cell Lung / Proto-Oncogene Proteins c-met / Drug Discovery / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: J Biol Chem Year: 2021 Type: Article Affiliation country: Netherlands

Fulltext

XML

PubMed Links

Search on Google