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The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local Ca2+ entry.
Kar, Pulak; Lin, Yu-Ping; Bhardwaj, Rajesh; Tucker, Charles J; Bird, Gary S; Hediger, Matthias A; Monico, Carina; Amin, Nader; Parekh, Anant B.
Affiliation
  • Kar P; Department of Physiology, Anatomy and Genetics, Oxford University, Oxford OX1 3PT, United Kingdom.
  • Lin YP; Department of Physiology, Anatomy and Genetics, Oxford University, Oxford OX1 3PT, United Kingdom.
  • Bhardwaj R; Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709.
  • Tucker CJ; Department of Nephrology and Hypertension, University Hospital Bern, Inselspital, 3010 Bern, Switzerland.
  • Bird GS; Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709.
  • Hediger MA; Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709.
  • Monico C; Department of Nephrology and Hypertension, University Hospital Bern, Inselspital, 3010 Bern, Switzerland.
  • Amin N; Micron Oxford Advanced Bioimaging Unit, Department of Biochemistry, Oxford University, Oxford OX1 3QU, United Kingdom.
  • Parekh AB; Department of Chemistry, Oxford University, Oxford OX1 3TA, United Kingdom.
Proc Natl Acad Sci U S A ; 118(19)2021 05 11.
Article in En | MEDLINE | ID: mdl-33941685
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium Channels / Signal Transduction / Calcium / NFATC Transcription Factors / A Kinase Anchor Proteins / ORAI1 Protein Type of study: Prognostic_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium Channels / Signal Transduction / Calcium / NFATC Transcription Factors / A Kinase Anchor Proteins / ORAI1 Protein Type of study: Prognostic_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Type: Article Affiliation country: United kingdom