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Investigation of Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in Children with Wilson Disease.
Durankus, Ferit; Albayrak, Yakup; Tokgöz, Yavuz; Beser, Ömer Faruk; Durankus, Ramazan; Çam, Sebahat; Sünnetçi, Eda; Akarsu, Ömer; Nural, Cemil; Erel, Özcan.
Affiliation
  • Durankus F; Department of Pediatrics, Göztepe Education and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
  • Albayrak Y; Faculty of Medicine, Department of Psychiatry, Tekirdag Namik Kemal University, Tekirdag, Turkey.
  • Tokgöz Y; Department of Pediatrics, Keçiören Education and Research Hospital, Health Sciences University, Ankara, Turkey.
  • Beser ÖF; Medical School, Department of Pediatric Gastroenterology, Cerrahpasa University, Istanbul, Turkey.
  • Durankus R; Department of Pediatrics, Göztepe Education and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
  • Çam S; Department of Pediatrics, Göztepe Education and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
  • Sünnetçi E; Medical School, Department of Pediatrics, Acibadem University, Istanbul, Turkey.
  • Akarsu Ö; Department of Microbiology, Göztepe Education and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
  • Nural C; Department of Clinical Biochemistry, Medical Faculty, Yildirim Beyazit University, Ankara, Turkey.
  • Erel Ö; Department of Clinical Biochemistry, Medical Faculty, Yildirim Beyazit University, Ankara, Turkey.
Fetal Pediatr Pathol ; 41(4): 576-583, 2022 Aug.
Article in En | MEDLINE | ID: mdl-33945395
ABSTRACT
BackgroundThe aim of the present study was to assess thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) levels in children with Wilson Disease (WD) and to compare them to healthy controls.

Methods:

Based on the inclusion and exclusion criteria, fifteen children with WD and twenty-nine healthy children were enrolled, and serum thiol/disulfide and IMA levels were compared between groups.

Results:

The mean values of native and total thiols were significantly lower in the WD group than in the control group. The mean value of disulfide was significantly higher in the WD group than in the control group. The mean percentages of disulfide/total thiol and native thiol/total thiol were higher in the WD group than in the control group. The IMA value was also higher in the WD group than in the control group.

Conclusion:

The present study demonstrating altered thiol/disulfide parameters indicates increased oxidative stress in children with WD.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Disulfides / Hepatolenticular Degeneration Limits: Child / Humans Language: En Journal: Fetal Pediatr Pathol Journal subject: PATOLOGIA / PEDIATRIA Year: 2022 Type: Article Affiliation country: Turkey
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Disulfides / Hepatolenticular Degeneration Limits: Child / Humans Language: En Journal: Fetal Pediatr Pathol Journal subject: PATOLOGIA / PEDIATRIA Year: 2022 Type: Article Affiliation country: Turkey