Therapeutic Approaches Targeting the Natural Killer-Myeloid Cell Axis in the Tumor Microenvironment.

Carnevalli, Larissa S; Ghadially, Hormas; Barry, Simon T

Carnevalli, Larissa S; Ghadially, Hormas; Barry, Simon T.

Affiliation

Carnevalli LS; Early Oncology, Research and Development, AstraZeneca, Cambridge, United Kingdom.
Ghadially H; Early Oncology, Research and Development, AstraZeneca, Cambridge, United Kingdom.
Barry ST; Early Oncology, Research and Development, AstraZeneca, Cambridge, United Kingdom.

Front Immunol ; 12: 633685, 2021.

Article in En | MEDLINE | ID: mdl-33953710

Subject(s)

Antineoplastic Agents, Immunological/therapeutic use; Immune Checkpoint Inhibitors/therapeutic use; Immunotherapy; Killer Cells, Natural/drug effects; Lymphocytes, Tumor-Infiltrating/drug effects; Myeloid-Derived Suppressor Cells/drug effects; Neoplasms/therapy; Tumor Microenvironment/drug effects; Animals; Antineoplastic Agents, Immunological/adverse effects; Cell Communication/drug effects; Humans; Immune Checkpoint Inhibitors/adverse effects; Immunity, Cellular/drug effects; Immunity, Humoral/drug effects; Killer Cells, Natural/immunology; Killer Cells, Natural/metabolism; Lymphocytes, Tumor-Infiltrating/immunology; Lymphocytes, Tumor-Infiltrating/metabolism; Myeloid-Derived Suppressor Cells/immunology; Myeloid-Derived Suppressor Cells/metabolism; Neoplasms/immunology; Neoplasms/metabolism; Neoplasms/pathology; Tumor Escape/drug effects

Key words

NK cell; cancer immunotherapy; immunotherapy; myeloid cell; tumor microenvironment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Killer Cells, Natural / Lymphocytes, Tumor-Infiltrating / Tumor Microenvironment / Myeloid-Derived Suppressor Cells / Antineoplastic Agents, Immunological / Immune Checkpoint Inhibitors / Immunotherapy / Neoplasms Limits: Animals / Humans Language: En Journal: Front Immunol Year: 2021 Type: Article Affiliation country: United kingdom

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