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A New Application of MALDI Biotyper for a Potential Use in Therapeutic Drug Monitoring of Voriconazole.
Falces-Romero, Iker; Mingorance, Jesús; García-Rodríguez, Julio; Cendejas-Bueno, Emilio.
Affiliation
  • Falces-Romero I; Clinical Microbiology and Parasitology Department, Hospital Universitario La Paz, IdiPaz, Madrid, Spain.
  • Mingorance J; Clinical Microbiology and Parasitology Department, Hospital Universitario La Paz, IdiPaz, Madrid, Spain.
  • García-Rodríguez J; Clinical Microbiology and Parasitology Department, Hospital Universitario La Paz, IdiPaz, Madrid, Spain.
  • Cendejas-Bueno E; Clinical Microbiology and Parasitology Department, Hospital Universitario La Paz, IdiPaz, Madrid, Spain.
Antimicrob Agents Chemother ; 65(8): e0245820, 2021 07 16.
Article in En | MEDLINE | ID: mdl-33972255
We present a proof-of-concept study on the use of MALDI Biotyper to detect and monitor the levels of voriconazole in human serum. A simple extraction-concentration method and a MALDI Biotyper protocol were developed, and a parent ion of voriconazole (1 H+) could be detected and quantified with good reproducibility. Our results point to a new application of MALDI Biotyper for therapeutic drug monitoring.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Monitoring Type of study: Guideline Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2021 Type: Article Affiliation country: Spain
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Monitoring Type of study: Guideline Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2021 Type: Article Affiliation country: Spain