The adenosine A<sub>2A</sub> receptor alleviates postoperative delirium-like behaviors by restoring blood cerebrospinal barrier permeability in rats.

Chen, Lei; Zhou, Ying; Wang, Jiayu; Li, Ke; Zhang, Zongze; Peng, Mian

The adenosine A_2A receptor alleviates postoperative delirium-like behaviors by restoring blood cerebrospinal barrier permeability in rats.

Chen, Lei; Zhou, Ying; Wang, Jiayu; Li, Ke; Zhang, Zongze; Peng, Mian.

Affiliation

Chen L; Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Zhou Y; Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Wang J; Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Li K; Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Zhang Z; Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Peng M; Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China.

J Neurochem ; 158(4): 980-996, 2021 08.

Article in En | MEDLINE | ID: mdl-34033116

Subject(s)

Adenosine A2 Receptor Antagonists/therapeutic use; Behavior, Animal/drug effects; Blood-Brain Barrier/drug effects; Delirium/drug therapy; Delirium/psychology; Postoperative Complications/drug therapy; Postoperative Complications/psychology; Receptor, Adenosine A2A/drug effects; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/analogs & derivatives; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/therapeutic use; Animals; Choroid Plexus/pathology; Delirium/chemically induced; Female; Maze Learning/drug effects; Permeability; Rats; Rats, Sprague-Dawley; Sodium Fluoride/cerebrospinal fluid; Tight Junction Proteins/metabolism; Tight Junctions/drug effects

Key words

RhoA; adenosine A2A receptor; blood cerebrospinal barrier; postoperative delirium; rho-associated protein kinase 2

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Postoperative Complications / Behavior, Animal / Blood-Brain Barrier / Delirium / Receptor, Adenosine A2A / Adenosine A2 Receptor Antagonists Limits: Animals Language: En Journal: J Neurochem Year: 2021 Type: Article Affiliation country: China

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