The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome.

Khalil, Jumana; Kato, Hiroki; Fujita, Takashi

Khalil, Jumana; Kato, Hiroki; Fujita, Takashi.

Affiliation

Khalil J; Laboratory of Virus Immunology, Institute for Frontier Life and Medical Science, Kyoto University, Kyoto 606-8507, Japan.
Kato H; Laboratory of Molecular and Cellular Immunology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8507, Japan.
Fujita T; Laboratory of Virus Immunology, Institute for Frontier Life and Medical Science, Kyoto University, Kyoto 606-8507, Japan.

Viruses ; 13(5)2021 05 11.

Article in En | MEDLINE | ID: mdl-34064604

Subject(s)

Disease Susceptibility; Phlebovirus/physiology; Severe Fever with Thrombocytopenia Syndrome/etiology; Viral Nonstructural Proteins/metabolism; Animals; Biomarkers; Cytokine Release Syndrome/etiology; Cytokine Release Syndrome/metabolism; Cytokines/metabolism; Disease Models, Animal; Host-Pathogen Interactions; Humans; Severe Fever with Thrombocytopenia Syndrome/complications; Severe Fever with Thrombocytopenia Syndrome/metabolism; Virus Replication

Key words

NF-κB; SFTSV NSs; TBK1; cytokine storm; innate immunity; interferons; viral pathogenesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phlebovirus / Viral Nonstructural Proteins / Disease Susceptibility / Severe Fever with Thrombocytopenia Syndrome Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Viruses Year: 2021 Type: Article Affiliation country: Japan

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