New Approach Methodology for Assessing Inhalation Risks of a Contact Respiratory Cytotoxicant: Computational Fluid Dynamics-Based Aerosol Dosimetry Modeling for Cross-Species and In Vitro Comparisons.

Corley, Richard A; Kuprat, Andrew P; Suffield, Sarah R; Kabilan, Senthil; Hinderliter, Paul M; Yugulis, Kevin; Ramanarayanan, Tharacad S

Corley, Richard A; Kuprat, Andrew P; Suffield, Sarah R; Kabilan, Senthil; Hinderliter, Paul M; Yugulis, Kevin; Ramanarayanan, Tharacad S.

Affiliation

Corley RA; Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
Kuprat AP; Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
Suffield SR; Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
Kabilan S; Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
Hinderliter PM; Syngenta Crop Protection, Greensboro, North Carolina 27409, USA.
Yugulis K; Battelle Memorial Institute, Columbus, Ohio 43201, USA.
Ramanarayanan TS; Syngenta Crop Protection, Greensboro, North Carolina 27409, USA.

Toxicol Sci ; 182(2): 243-259, 2021 08 03.

Article in En | MEDLINE | ID: mdl-34077545

Subject(s)

Hydrodynamics; Lung; Administration, Inhalation; Aerosols/toxicity; Animals; Computer Simulation; Humans; Models, Biological; Particle Size; Rats

Key words

CFD; CFPD; aerosol clearance; aerosol deposition; chlorothalonil; risk assessment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hydrodynamics / Lung Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2021 Type: Article Affiliation country: United States

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