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Restoring VTA DA neurons excitability accelerates emergence from sevoflurane general anesthesia of anxiety state.
Wang, Hui; Yu, Le; Qin, Yuan-Jun; Chen, Ming; Wang, Xin; Luo, Huo-Qing; Cong, Pei-Lin; Wang, Xiao-Li; Cai, Hong-Miao; Zhang, Ai-Lian; Sun, Xiao-Hui; Li, Zhao; Xue, Ming; Sun, Na; Wang, Qing-Xiu; Hu, Ji.
Affiliation
  • Wang H; Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
  • Yu L; Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
  • Qin YJ; Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
  • Chen M; School of Life Science and Technology, Shanghai Tech University, Shanghai, 201210, China.
  • Wang X; Department of Anesthesiology, Shanghai No.9 Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200082, China.
  • Luo HQ; School of Life Science and Technology, Shanghai Tech University, Shanghai, 201210, China.
  • Cong PL; Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, 200120, China.
  • Wang XL; Department of Anesthesiology, Shanghai No.9 Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200082, China.
  • Cai HM; Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
  • Zhang AL; Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
  • Juan-Guo; Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710000, Shaanxi, China.
  • Sun XH; Department of Anesthesiology, Shanghai No.9 Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200082, China.
  • Li Z; Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
  • Xue M; Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
  • Sun N; Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
  • Wang QX; Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China. Electronic address: qxw1123@126.com.
  • Hu J; School of Life Science and Technology, Shanghai Tech University, Shanghai, 201210, China. Electronic address: huji@shanghaitech.edu.cn.
Biochem Biophys Res Commun ; 565: 21-28, 2021 08 06.
Article in En | MEDLINE | ID: mdl-34090206
Preoperative anxiety is common and often comes with a higher probability of worse recovery. However, the neurological mechanism of the effect of preoperative anxiety on general anesthesia and subsequent awakening remains unknown. In this study, we report an anxious state results in delayed awakening in anxiety model mice from sevoflurane general anesthesia. More profound inhibition of DA neurons in the VTA contributes to delayed awakening. Optogenetic stimulation of VTA DA neurons can reverse the delay. The results indicate that VTA DA neurons may be involved in the delay in awakening from general anesthesia caused by anxiety.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anxiety / Ventral Tegmental Area / Anesthetics, Inhalation / Dopaminergic Neurons / Sevoflurane Limits: Animals Language: En Journal: Biochem Biophys Res Commun Year: 2021 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anxiety / Ventral Tegmental Area / Anesthetics, Inhalation / Dopaminergic Neurons / Sevoflurane Limits: Animals Language: En Journal: Biochem Biophys Res Commun Year: 2021 Type: Article Affiliation country: China