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Identification of ortho catechol-containing isoflavone as a privileged scaffold that directly prevents the aggregation of both amyloid ß plaques and tau-mediated neurofibrillary tangles and its in vivo evaluation.
Son, Seung Hwan; Do, Ji Min; Yoo, Ji-Na; Lee, Hyun Woo; Kim, Nam Kwon; Yoo, Hyung-Seok; Gee, Min Sung; Kim, Jong-Ho; Seong, Ji Hye; Inn, Kyung-Soo; Seo, Min-Duk; Lee, Jong Kil; Kim, Nam-Jung.
Affiliation
  • Son SH; College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
  • Do JM; Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
  • Yoo JN; College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon 16499, Republic of Korea; Department of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of Korea.
  • Lee HW; College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
  • Kim NK; Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
  • Yoo HS; College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
  • Gee MS; College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
  • Kim JH; College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
  • Seong JH; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
  • Inn KS; College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
  • Seo MD; College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon 16499, Republic of Korea; Department of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of Korea. Electronic address: mdseo@ajou.ac.kr.
  • Lee JK; College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address: jklee3984@khu.ac.kr.
  • Kim NJ; College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address: kimnj@khu.ac.kr.
Bioorg Chem ; 113: 105022, 2021 08.
Article in En | MEDLINE | ID: mdl-34098397
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Catechols / Tau Proteins / Neuroprotective Agents / Isoflavones Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Bioorg Chem Year: 2021 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Catechols / Tau Proteins / Neuroprotective Agents / Isoflavones Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Bioorg Chem Year: 2021 Type: Article